NDLI: Fusion Peptides from Oncogenic Chimeric Proteins as Putative Specific Biomarkers of Cancer*

Content Provider	PubMed Central
Author	Conlon, Kevin P. Basrur, Venkatesha Rolland, Delphine Wolfe, Thomas Nesvizhskii, Alexey I. Maccoss, Michael J. Lim, Megan S. Elenitoba-johnson, Kojo S. J.
Copyright Year	2013
Abstract	Chromosomal translocations encoding chimeric fusion proteins constitute one of the most common mechanisms underlying oncogenic transformation in human cancer. Fusion peptides resulting from such oncogenic chimeric fusions, though unique to specific cancer subtypes, are unexplored as cancer biomarkers. Here we show, using an approach termed fusion peptide multiple reaction monitoring mass spectrometry, the direct identification of different cancer-specific fusion peptides arising from protein chimeras that are generated from the juxtaposition of heterologous genes fused by recurrent chromosomal translocations. Using fusion peptide multiple reaction monitoring mass spectrometry in a clinically relevant scenario, we demonstrate the specific, sensitive, and unambiguous detection of a specific diagnostic fusion peptide in clinical samples of anaplastic large cell lymphoma, but not in a diverse array of benign lymph nodes or other forms of primary malignant lymphomas and cancer-derived cell lines. Our studies highlight the utility of fusion peptides as cancer biomarkers and carry broad implications for the use of protein biomarkers in cancer detection and monitoring.
Related Links	http://dx.doi.org/10.1074/mcp.m113.029926
Ending Page	2723
Page Count	10
Starting Page	2714
File Format	PDF
ISSN	15359476
e-ISSN	15359484
Journal	Molecular & Cellular Proteomics : MCP
Issue Number	10
Volume Number	12
Language	English
Publisher	The American Society for Biochemistry and Molecular Biology
Publisher Date	2013-10-01
Access Restriction	Open
Rights Holder	The American Society for Biochemistry and Molecular Biology
Subject Keyword	Analytical Chemistry Biochemistry Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Analytical Chemistry Molecular Biology Biochemistry

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