NDLI: MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer

Content Provider	PubMed Central
Author	Dudda, Jan C. Salaun, Bruno Ji, Yun Palmer, Douglas C. Monnot, Gwennaelle C. Merck, Estelle Caroline, Boudousquie Utzschneider, Daniel T. Escobar, Thelma M. Perret, Rachel A., Muljo Stefan Hebeisen, Michael Rufer, Nathalie Dietmar, Zehn Donda, Alena Restifo, Nicholas P. Held, Werner Luca, Gattinoni Romero, Pedro
Abstract	MicroRNAs regulate the function of several immune cells but their role in promoting CD8+ T-cell immunity remains unknown. Here we report that miR-155 is required for CD8+ T-cell responses to both virus and cancer. In the absence of miR-155, accumulation of effector CD8+ T cells was severely reduced during acute and chronic viral infections and control of virus replication was impaired. Similarly, Mir155-/- CD8+ T cells were in effective at controlling tumor growth, whereas miR-155 overexpression enhanced the antitumor response. miR-155 deficiency resulted in accumulation of SOCS-1 causing defective cytokine signaling through STAT5. Consistently, enforced expression of SOCS-1 in CD8+ T cells phenocopied the miR-155 deficiency, whereas SOCS-1 silencing augmented tumor destruction. These findings identify miR-155 and its target SOCS-1 as key regulators of effector CD8+ T cells that can be modulated to potentiate immunotherapies for infectious diseases and cancer.
Related Links	http://dx.doi.org/10.1016/j.immuni.2012.12.006
Ending Page	753
Page Count	12
Starting Page	742
File Format	PDF
ISSN	10747613
e-ISSN	10974180
Journal	Immunity
Issue Number	4
Volume Number	38
Language	English
Publisher Date	2013-04-01
Access Restriction	Open
Subject Keyword	Immunology Immunology and Allergy Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Allergy Immunology

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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