Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | PubMed Central |
|---|---|
| Author | Barao, Isabel Wright, Paul W. Sungur, Can M. Anderson, Stephen K. Doug, Redelman Murphy, William J. |
| Copyright Year | 2013 |
| Abstract | Inhibitory NK cell receptors specific for major histocompatibility complex class I (MHC-I) molecules include Ly49 receptors in mice and killer immunoglobulin-like receptors (KIR) in humans. The “licensing” or “arming” models imply that engagement of these receptors to self-MHC-I molecules during NK cell development educate NK cells to be more responsive to cancer and viral infection. We recently reported that hematopoietic stem cell transplantation (HSCT) induced rapid and preferential expansion of functionally competent Ly49G+, but not other Ly49 family members, NK cells independently of NK-cell licensing via Ly49-MHC-I interactions. We now extend these studies to determine the expression of the two Ly49G receptor isoforms, Ly49GB6 and Ly49GBALB, using mice with different MHC-I haplotypes that express one or both of the isoforms. NK cells from CB6F1 (H-2bxd) hybrid mice express two different alleles for Ly49G receptor (Ly49GB6 and Ly49GBALB). Here, we found that CB6F1 mice had more Ly49GB6+ than Ly49BALB+ NK cells, and that only Ly49GB6+ NK cells increased in relative numbers and in Ly49G MFIs after HSCT similar to the B6 parental strain. We further observed that Ly49G+ NK cells in BALB/c (H-2d) and BALB.B (H-2b), which have the same background genes, hosts slowly recover after HSCT, in contrast to Ly49G+ NK cells in B6 (H-2b) recipients. The difference in expression of Ly49GB6 relative to Ly49GBALB was linked to differences in the activity of the Pro1 promoter between the two alleles. Therefore, we conclude that the Ly49GB6 receptor dominates Ly49G expression on NK cells after HSCT in strains where that allele is expressed. The data suggest that Ly49 allelic polymorphism within a particular Ly49 family member can differentially affect NK cell recovery after HSCT depending on the background genes of the recipient and not on the MHC-I haplotype. |
| Related Links | http://dx.doi.org/10.1016/j.bbmt.2013.07.021 |
| Ending Page | 1452 |
| Page Count | 7 |
| Starting Page | 1446 |
| File Format | |
| ISSN | 10838791 |
| e-ISSN | 15236536 |
| Journal | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation |
| Issue Number | 10 |
| Volume Number | 19 |
| Language | English |
| Publisher Date | 2013-10-01 |
| Access Restriction | Open |
| Subject Keyword | Transplantation Hematology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Transplantation |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|