NDLI: Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer

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Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer

Content Provider	PubMed Central
Author	Dongen, Mallory A. Van Desai, Ankur Orr, Bradford G. Baker, James R. Holl, Mark M. Banaszak
Copyright Year	2013
Abstract	Although methods have been developed to synthesize and isolate generation 5 (G5) PAMAM dendrimers containing precise numbers of ligands per polymer particle, the presence of skeletal and generational defects in this material can substantially hamper the process. Here we provide a quantitative analysis of G5 PAMAM dendrimer defects via high performance liquid chromatography, potentiometric titration, mass spectrometry, size exclusion chromatography, and nuclear magnetic resonance. We identified, isolated, and characterized the major structural defects of G5 dendrimer, trailing generations, and dimer, trimer, and tetramer species. We determine that the G5 material present in the as-received mixture contains 93 arms on average. We have developed two model systems capable of generating the experimentally observed mass range and polydispersity at defect rates of 8–15%.
Related Links	http://dx.doi.org/10.1016/j.polymer.2013.05.062
Ending Page	4133
Page Count	8
Starting Page	4126
File Format	PDF
ISSN	00323861
Journal	Polymer
Issue Number	16
Volume Number	54
Language	English
Publisher Date	2013-07-01
Access Restriction	Open
Subject Keyword	Organic Chemistry Polymers and Plastics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Materials Chemistry Polymers and Plastics

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