NDLI: Mechanics of the Mitral Annulus in Chronic Ischemic Cardiomyopathy

Content Provider	PubMed Central
Author	Rausch, Manuel K. Tibayan, Frederick A. Ingels, Neil B. Miller, D. Craig Kuhl, Ellen
Abstract	Approximately one third of all patients undergoing open-heart surgery for repair of ischemic mitral regurgitation present with residual and recurrent mitral valve leakage upon follow up. A fundamental quantitative understanding of mitral valve remodeling following myocardial infarction may hold the key to improved medical devices and better treatment outcomes. Here we quantify mitral annular strains and curvature in nine sheep 5 ± 1 weeks after controlled inferior myocardial infarction of the left ventricle. We complement our marker-based mechanical analysis of the remodeling mitral valve by common clinical measures of annular geometry before and after the infarct. After 5 ± 1 weeks, the mitral annulus dilated in septal-lateral direction by 15.2% (p=0.003) and in commissure-commissure direction by 14.2% (p<0.001). The septal annulus dilated by 10.4% (p=0.013) and the lateral annulus dilated by 18.4% (p<0.001). Remarkably, in animals with large degree of mitral regurgitation and annular remodeling, the annulus dilated asymmetrically with larger distortions toward the lateral-posterior segment. Strain analysis revealed average tensile strains of 25% over most of the annulus with exception for the lateral-posterior segment, where tensile strains were 50% and higher. Annular dilation and peak strains were closely correlated to the degree of mitral regurgitation. A complementary relative curvature analysis revealed a homogenous curvature decrease associated with significant annular circularization. All curvature profiles displayed distinct points of peak curvature disturbing the overall homogenous pattern. These hinge points may be the mechanistic origin for the asymmetric annular deformation following inferior myocardial infarction. In the future, this new insight into the mechanism of asymmetric annular dilation may support improved device designs and possibly aid surgeons in reconstructing healthy annular geometry during mitral valve repair.
Related Links	http://dx.doi.org/10.1007/s10439-013-0813-7
Ending Page	2180
Page Count	10
Starting Page	2171
File Format	PDF
ISSN	00906964
e-ISSN	15739686
Journal	Annals of biomedical engineering
Issue Number	10
Volume Number	41
Language	English
Publisher Date	2013-10-01
Access Restriction	Open
Subject Keyword	Biomedical Engineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mechanics of the Mitral Annulus in Chronic Ischemic Cardiomyopathy

Mitral valve function following ischemic cardiomyopathy: a biomechanical perspective

In Vivo Dynamic Deformation of the Mitral Valve Annulus

In Vivo Dynamic Deformation of the Mitral Valve Annulus

Influence of Ventricular Pressure Drop on Mitral Annulus Dynamics Through the Process of Vortex Ring Formation

Characterization of Mitral Valve Annular Dynamics in the Beating Heart

Effect of Strut Chordae Transection on Mitral Valve Leaflet Biomechanics

A Novel, Innovative Ovine Model of Chronic Ischemic Cardiomyopathy Induced by Multiple Coronary Ligations

Finite element analysis of the mitral apparatus: annulus shape effect and chordal force distribution

Mechanics of the Mitral Annulus in Chronic Ischemic Cardiomyopathy

Similar Documents

Mechanics of the Mitral Annulus in Chronic Ischemic Cardiomyopathy

Mitral valve function following ischemic cardiomyopathy: a biomechanical perspective

In Vivo Dynamic Deformation of the Mitral Valve Annulus

In Vivo Dynamic Deformation of the Mitral Valve Annulus

Influence of Ventricular Pressure Drop on Mitral Annulus Dynamics Through the Process of Vortex Ring Formation

Characterization of Mitral Valve Annular Dynamics in the Beating Heart

Effect of Strut Chordae Transection on Mitral Valve Leaflet Biomechanics

A Novel, Innovative Ovine Model of Chronic Ischemic Cardiomyopathy Induced by Multiple Coronary Ligations

Finite element analysis of the mitral apparatus: annulus shape effect and chordal force distribution

Mechanics of the Mitral Annulus in Chronic Ischemic Cardiomyopathy