NDLI: A Methanol Extract of Adansonia digitata L. Leaves Inhibits Pro-Inflammatory iNOS Possibly via the Inhibition of NF-κB Activation

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A Methanol Extract of Adansonia digitata L. Leaves Inhibits Pro-Inflammatory iNOS Possibly via the Inhibition of NF-κB Activation

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A Methanol Extract of Adansonia digitata L. Leaves Inhibits Pro-Inflammatory iNOS Possibly via the Inhibition of NF-κB Activation

Content Provider	PubMed Central
Author	Ayele, Yihunie Kim, Jung-ah Park, Eunhee Kim, Ye-jung Retta, Negussie Dessie, Gulelat Rhee, Sang-ki Koh, Kwangoh Nam, Kung-woo Kim, Hee Seon
Copyright Year	2013
Abstract	This study examined the total polyphenol content of eight wild edible plants from Ethiopia and their effect on NO production in Raw264.7 cells. Owing to its relatively high polyphenol concentration and inhibition of NO production, the methanol extract of Adansonia digitata L. leaf (MEAD) was subjected to detailed evaluation of its antioxidant and anti-inflammatory effects. Antioxidant effects were assessed by measuring free-radical-scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and oxygen-radical-absorbance capacity (ORAC) assays, while anti-inflammatory effects were assessed by measuring inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. In the ORAC assay, MEAD was 10.2 times more potent than vitamin C at eliminating peroxyl radicals. In DPPH assay, MEAD also showed a strong ROS scavenging effect. MEAD significantly inhibited iNOS activity (IC50=28.6 μg/ml) of LPS-stimulated Raw264.7 cells. We also investigated the relationship between iNOS expression and nuclear factor kappa B (NF-κB) activation. MEAD inhibited IκBα degradation and NF-κB translocation from the cytosol to the nucleus in LPS-induced RAW264.7 cells without significant cytotoxic effects, as confirmed by MTT assay. These results suggest that MEAD inhibits anti-inflammatory iNOS expression, which might be related to the elimination of peroxyl radicals and thus the inhibition of IκBα-mediated NF-κB signal transduction.
Related Links	http://dx.doi.org/10.4062/biomolther.2012.098
Ending Page	152
Page Count	7
Starting Page	146
File Format	PDF
ISSN	19769148
e-ISSN	20054483
Journal	Biomolecules & Therapeutics
Issue Number	2
Volume Number	21
Language	English
Publisher	The Korean Society of Applied Pharmacology
Publisher Date	2013-03-31
Access Restriction	Open
Rights Holder	The Korean Society of Applied Pharmacology
Subject Keyword	Molecular Medicine Biochemistry Pharmacology Drug Discovery Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Biochemistry Molecular Medicine Pharmacology

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