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| Content Provider | PubMed Central |
|---|---|
| Author | Stelzer, Yonatan Ronen, Daniel Bock, Christoph Boyle, Patrick Meissner, Alexander Nissim, Benvenisty |
| Copyright Year | 2013 |
| Abstract | Parental imprinting is an epigenetic phenomenon by which genes are expressed in a monoallelic fashion, according to their parent of origin. DNA methylation is considered the hallmark mechanism regulating parental imprinting. To identify imprinted differentially methylated regions (DMRs), we compared the DNA methylation status between multiple normal and parthenogenetic human pluripotent stem cells (PSCs) by performing reduced representation bisulfite sequencing. Our analysis identified over 20 previously unknown imprinted DMRs in addition to the known DMRs. These include DMRs in loci associated with human disorders, and a class of intergenic DMRs that do not seem to be related to gene expression. Furthermore, the study showed some DMRs to be unstable, liable to differentiation or reprogramming. A comprehensive comparison between mouse and human DMRs identified almost half of the imprinted DMRs to be species specific. Taken together, our data map novel DMRs in the human genome, their evolutionary conservation, and relation to gene expression. |
| Related Links | http://dx.doi.org/10.1016/j.stemcr.2013.03.005 |
| Ending Page | 89 |
| Page Count | 11 |
| Starting Page | 79 |
| File Format | |
| ISSN | 22136711 |
| e-ISSN | 22136711 |
| Journal | Stem Cell Reports |
| Issue Number | 1 |
| Volume Number | 1 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-06-01 |
| Access Restriction | Open |
| Rights Holder | Elsevier |
| Subject Keyword | Healthcare Stem Cell Stem Cells International genetics Medicine Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Genetics Developmental Biology Biochemistry |
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