NDLI: Regulatory B cells in autoimmune diseases and mucosal immune homeostasis

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Regulatory B cells in autoimmune diseases and mucosal immune homeostasis

Content Provider	PubMed Central
Author	Li, Xiaoxiao Braun, Jonathan Wei, Bo
Abstract	B lymphocytes contribute to physiological immunity through organogenesis of secondary lymphoid organs, presentation of antigen to T cells, production of antibodies, and secretion of cytokines. Their role in several autoimmune diseases, mainly as producers of pathogenic antibodies, is also well known. However, certain subsets of B cells are emerging as the important regulatory cell populations in both mouse and human. The regulatory functions of B cells have been demonstrated in a variety of mouse models of autoimmune diseases including collagen-induced arthritis (CIA), experiment autoimmune encephalomyelitis (EAE), anterior chamber-associated immune deviation (ACAID), diabetes, contact hypersensitivity (CHS), and intestinal mucosal inflammation. Accumulating evidence from both mouse and human studies confirms the existence of regulatory B cells, and is beginning to define their mechanisms of action. In this article, we first review the history of B cells with regulatory function in autoimmune diseases, and summarize the current understanding about the characterizations of such B-cell subsets. We then discuss the possible regulatory mechanisms of B cells, and specifically define the role of regulatory B cells in immune homeostasis in the intestine.
Related Links	http://dx.doi.org/10.3109/08916931003782189
Ending Page	68
Page Count	11
Starting Page	58
File Format	PDF
ISSN	08916934
e-ISSN	1607842X
Journal	Autoimmunity
Issue Number	1
Volume Number	44
Language	English
Publisher Date	2011-02-01
Access Restriction	Open
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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