NDLI: Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

Content Provider	PubMed Central
Author	Caraiscos, Valerie B. Elliott, Erin M. You-ten, Kong E. Cheng, Victor Y. Delia, Belelli Newell, J. Glen Jackson, Michael F. Lambert, Jeremy J. Rosahl, Thomas W. Wafford, Keith A. Macdonald, John F. Orser, Beverley A.
Copyright Year	2004
Abstract	The principal inhibitory neurotransmitter in the mammalian brain, γ-aminobutyric acid (GABA), is thought to regulate memory processes by activating transient inhibitory postsynaptic currents. Here we describe a nonsynaptic, tonic form of inhibition in mouse CA1 pyramidal neurons that is generated by a distinct subpopulation of GABA type A receptors (GABAARs). This tonic inhibitory conductance is predominantly mediated by α5 subunit-containing GABAARs (α5GABAARs) that have different pharmacological and kinetic properties compared to postsynaptic receptors. GABAARs that mediate the tonic conductance are well suited to detect low, persistent, ambient concentrations of GABA in the extracellular space because they are highly sensitive to GABA and desensitize slowly. Moreover, the tonic current is highly sensitive to enhancement by amnestic drugs. Given the restricted expression of α5GABAARs to the hippocampus and the association between reduced α5GABAAR function and improved memory performance in behavioral studies, our results suggest that tonic inhibition mediated by α5GABAARs in hippocampal pyramidal neurons plays a key role in cognitive processes.
Related Links	http://dx.doi.org/10.1073/pnas.0307231101
Ending Page	3667
Page Count	6
Starting Page	3662
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	101
Language	English
Publisher	National Academy of Sciences
Publisher Date	2004-03-09
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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