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The Efficacy of an Immunoisolating Membrane System for Islet Xenotransplantation in Minipigs
| Content Provider | PubMed Central |
|---|---|
| Author | Neufeld, Tova Ludwig, Barbara Barkai, Uriel Weir, Gordon C. Colton, Clark K. Evron, Yoav Maria, Balyura Karina, Yavriyants Zimermann, Baruch Azarov, Dmitri Maimon, Shiri Shabtay, Noa Tania, Rozenshtein Lorber, Dana Steffen, Anja Udi, Willenz Bloch, Konstantine Vardi, Pnina Taube, Ran Vos, Paul De Lewis, Eli C. Bornstein, Stefan R. Rotem, Avi |
| Editor | Maedler, Kathrin |
| Copyright Year | 2013 |
| Abstract | Developing a device that protects xenogeneic islets to allow treatment and potentially cure of diabetes in large mammals has been a major challenge in the past decade. Using xenogeneic islets for transplantation is required in light of donor shortage and the large number of diabetic patients that qualify for islet transplantation. Until now, however, host immunoreactivity against the xenogeneic graft has been a major drawback for the use of porcine islets. Our study demonstrates the applicability of a novel immunoprotective membrane that allows successful xenotransplantation of rat islets in diabetic minipigs without immunosuppressive therapy. Rat pancreatic islets were encapsulated in highly purified alginate and integrated into a plastic macrochamber covered by a poly-membrane for subcutaneous transplantation. Diabetic Sinclair pigs were transplanted and followed for up to 90 days. We demonstrated a persistent graft function and restoration of normoglycemia without the need for immunosuppressive therapy. This concept could potentially offer an attractive strategy for a more widespread islet replacement therapy that would restore endogenous insulin secretion in diabetic patients without the need for immunosuppressive drugs and may even open up an avenue for safe utilization of xenogeneic islet donors. |
| Related Links | http://dx.doi.org/10.1371/journal.pone.0070150 |
| Starting Page | 70150 |
| File Format | |
| ISSN | 19326203 |
| e-ISSN | 19326203 |
| Journal | PLoS ONE |
| Issue Number | 8 |
| Volume Number | 8 |
| Language | English |
| Publisher | Public Library of Science |
| Access Restriction | Open |
| Rights Holder | Public Library of Science |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
