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| Content Provider | PubMed Central |
|---|---|
| Author | Kim, Dae Hyun Kim, Chul Ding, Eric L. Townsend, Mary K. Lipsitz, Lewis A. |
| Abstract | Animal studies and small-controlled studies in humans suggest that adiponectin may regulate blood pressure via brain-mediated and endothelium-mediated mechanisms. We conducted a systematic review and meta-analysis to evaluate the epidemiologic evidence on plasma adiponectin levels and hypertension in free-living adult population. A systematic search of Medline and EMBASE, up to February 2013, identified 43 non-prospective and 5 prospective studies that included 17,598 adults (8,220 with hypertension; mean age 19–69 years; and mean body mass index 22–38 kg/m2). Two investigators independently extracted data on adiponectin levels by hypertension status and dose-response relationship. We used a random-effects model to compute the weighted mean difference in adiponectin levels between hypertensive and normotensive adults and a 2-stage generalized linear-square methods to compute the odds ratio of hypertension per 1 μg/ml increase in adiponectin. Hypertensive adults had 1.64 μg/ml (95% confidence interval: −2.07, −1.21) lower adiponectin levels than normotensive adults. Every 1 μg/ml increase in adiponectin levels was associated with 6% reduced risk of hypertension (95% confidence interval: 0.92, 0.97). These findings were consistent across study design and characteristics, including age, gender, and body mass index (p>0.05). However, our meta-analysis was limited by unexplained large between-study heterogeneity, a small number of prospective studies, and selective reporting of dose-response data. In conclusion, epidemiologic evidence suggests that plasma adiponectin level is a biomarker and possible mediator in the development of adiposity-related hypertension. The question remains as to adiponectin as a potential therapeutic target and its relationship with other adipokines in blood pressure regulation. |
| Related Links | http://dx.doi.org/10.1161/hypertensionaha.113.01453 |
| Ending Page | 32 |
| Page Count | 6 |
| Starting Page | 27 |
| File Format | |
| ISSN | 0194911X |
| e-ISSN | 15244563 |
| Journal | Hypertension |
| Issue Number | 1 |
| Volume Number | 62 |
| Language | English |
| Publisher Date | 2013-07-01 |
| Access Restriction | Open |
| Subject Keyword | Internal Medicine Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine |
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