Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | PubMed Central |
|---|---|
| Author | Conrad, Gary L. Rau, Eric E. Shine, Kenneth I. |
| Abstract | We studied whether creatine kinase appearance in venous effluent was specific for, and quantitatively proportional to, the amount of loss of functioning myocardium. Cell viability was determined by simultaneously monitoring tissue 42K content and mechanical performance during anoxia and reoxygenation in isolated, arterially perfused, interventricular rabbit septa. The septa were paced at 42 beats/min and perfused at 1.8 ml/min per g tissue with a modified Tyrode solution at 28°C. Net total creatine kinase losses of 5.3±2.7, 20.6±7.2, 55.3±7.6, and 110.7±27.1 IU/g dry wt (mean±SEM) were observed after 20, 30, 40, and 60 min of anoxia, respectively. Maximum 42K losses during the same intervals of anoxia were 16.8±3.4, 38.3±2.9, 47.0±1.4, and 84.3±14.8 mmol K+/kg dry wt and correlated with creatine kinase losses, r = 0.97. Upon reoxygenation, 42K content returned to a new plateau which was expressed as a percentage of decrease from control content. These unrecovered 42K losses were −2.7±0.9, 0.7±2.9, 6.6±1.9, and 14.0±6.5% after 20, 30, 40, and 60 min of anoxia, respectively, and correlated with the creatine kinase loss, r = 0.97. Net loss of developed tension after reoxygenation was 9.0±2.3, 26.7±17.9, 31.7±1.1, and 60.7±8.8% of control after these anoxic intervals and correlated with creatine kinase loss, r = 0.92. The small enzyme loss that occurred after 20 min anoxia without evidence for irreversible loss of cell function was ≅0.1% of total tissue enzyme content. The significant correlation of enzyme loss with the irreversible losses of potassium content and contractile performance supported the hypothesis that creatine kinase appearance in the venous effluent was the result of cell death. |
| Related Links | http://dx.doi.org/10.1172/jci109434 |
| Ending Page | 161 |
| Page Count | 7 |
| Starting Page | 155 |
| File Format | |
| ISSN | 00219738 |
| Journal | Journal of Clinical Investigation |
| Issue Number | 1 |
| Volume Number | 64 |
| Language | English |
| Publisher Date | 1979-07-01 |
| Access Restriction | Open |
| Subject Keyword | Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|