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| Content Provider | PubMed Central |
|---|---|
| Author | Zhao, Yanmin Huang, He Wei, Guoqing |
| Copyright Year | 2013 |
| Abstract | New genetic markers for adult acute lymphoblastic leukemia (ALL) have been found to have prognostic impact, such as the lymphoid transcription factor gene IKZF1 alterations, which are associated with a high rate of leukemic relapse in B-ALL. Although complete remission rates by induction chemotherapy in ALL are now high, the long-term survival is still disappointing. Improvements in the survival outcome of ALL have been observed in young adults as a result of the use of pediatric inspired regimens and the broadening of the number of patients who are eligible for allogeneic SCT. Development of new and less toxic agents also provide promise to improve the outcome in adult ALL, such as tyrosine kinase inhibitors in Ph-positive ALL, rituximab in CD20-positive disease, blinatumomab in precursor B-ALL and nelarabine in T-lineage ALL. Challenges for the future are to implement genomic profiling into the clinical setting to guide risk stratification and providing novel targets for tailored therapies. |
| Related Links | http://dx.doi.org/10.1186/1756-8722-6-40 |
| Ending Page | 40 |
| Page Count | 1 |
| Starting Page | 40 |
| File Format | |
| ISSN | 17568722 |
| e-ISSN | 17568722 |
| Journal | Journal of Hematology & Oncology |
| Volume Number | 6 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Rights Holder | BioMed Central |
| Subject Keyword | Cancer Research Oncology Molecular Biology Hematology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Hematology Cancer Research Oncology |
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