NDLI: Specific HLA-DRB and -DQB Alleles and Haplotypes Confer Disease Susceptibility or Resistance in Bahraini Type 1 Diabetes Patients

Content Provider	PubMed Central
Author	Al Harbi, Einas M. Abbassi, Abdul-jabbar Tamim, Hala Al-jenaidi, Fayza Mariam, Kooheji Kamal, Madeeha Al-mahroos, Salwa Al Nasir, Faisal Motala, Ayesha A. Almawi, Wassim Y.
Copyright Year	2004
Abstract	Insofar as genetic susceptibility to type 1 diabetes is associated with HLA class II genes, with certain allelic combinations conferring disease susceptibility or resistance, this study assessed the distributions of HLA-DR and -DQ among 107 unrelated patients with type 1 diabetes and 88 healthy controls from Bahrain, all of Arab origin. The HLA-DRB and -DQB genotypes were determined by PCR-sequence-specific priming. The following alleles showed the strongest association with type 1 diabetes among patients versus controls according to their frequencies: DRB1030101 (0.430 versus 0.097; P < 0.001), DRB1040101 (0.243 versus 0.034; P < 0.001), DQB10201 (0.467 versus 0.193; P < 0.001), and DQB10302 (0.229 versus 0.091; P < 0.001). When the frequencies of alleles in controls were compared to those in patients, negative associations were seen for DRB1100101 (0.085 versus 0.014; P < 0.001), DRB1110101 (0.210 versus 0.060; P < 0.001), DQB1030101 (0.170 versus 0.075; P = 0.006), and DQB1050101 (0.335 versus 0.121; P < 0.001). In addition, the DRB1030101-DQB10201 (70.1 versus 22.7%; P < 0.001) and DRB1030101-DQB10302 (21.5 versus 0.0%; P < 0.001) genotypes were more prevalent among patients, thereby conferring disease susceptibility, whereas the DRB1100101-DQB1050101 (20.5 versus 2.8%; P < 0.001), DRB1110101-DQB1030101 (28.4 versus 8.4%; P < 0.001), and DRB1110101-DQB1050101 (30.7 versus 0.9%; P < 0.001) genotypes were more prevalent among controls, thus assigning a protective role. These results confirm the association of specific HLA-DR and -DQ alleles and haplotypes with type 1 diabetes and may underline several characteristics that distinguish Bahraini patients from other Caucasians patients.
Related Links	http://dx.doi.org/10.1128/cdli.11.2.292-296.2004
Ending Page	296
Page Count	5
Starting Page	292
File Format	PDF
ISSN	15566811
e-ISSN	10986588
Journal	Clinical and Diagnostic Laboratory Immunology
Issue Number	2
Volume Number	11
Language	English
Publisher	American Society for Microbiology
Publisher Date	2004-03-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Immunology Immunology and Allergy Microbiology (medical) Clinical Biochemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Clinical Biochemistry Immunology Microbiology (medical)

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