NDLI: Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase In Lung CD103+ But Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4+ T cells and Promote Airway Tolerance

Content Provider	PubMed Central
Author	Khare, Anupriya Krishnamoorthy, Nandini Oriss, Timothy B. Fei, Mingjian Ray, Prabir Ray, Anuradha
Abstract	Dendritic cell (DC)-T cell interactions that underlie iTreg generation and airway tolerance are not well understood. Here we show that mice lacking CD11chi lung DCs but containing pDCs fail tolerization with inhaled antigen and cannot support Foxp3 induction in vivo in naïve CD4+ T cells. CD103+ DCs from tolerized mice efficiently induced Foxp3 in co-cultured naïve CD4+ T cells but pDCs and lung macrophages failed to do so. CD103+ DCs, but not pDCs or lung macrophages, upregulated expression of retinaldehyde dehydrogenase 2 (aldh1a2) that is key for production of retinoic acid, a co-factor for TGF-β for Foxp3 induction. Batf3−/− mice, selectively lacking CD103+ DCs, failed tolerization by inhaled antigen. Collectively, our data show that pulmonary tolerance is dependent on CD103+DCs, correlating with their ability to upregulate aldh1a2, which can promote FoxP3 expression in T cells.
Related Links	http://dx.doi.org/10.4049/jimmunol.1300193
Ending Page	29
Page Count	5
Starting Page	25
File Format	PDF
ISSN	00221767
e-ISSN	15506606
Journal	Journal of immunology (Baltimore, Md. : 1950)
Issue Number	1
Volume Number	191
Language	English
Publisher Date	2013-07-01
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase In Lung CD103+ But Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4+ T cells and Promote Airway Tolerance