NDLI: FETAL BETAMETHASONE EXPOSURE ATTENUATES ANGIOTENSIN-(1-7)-MAS RECEPTOR EXPRESSION IN THE DORSAL MEDULLA OF ADULT SHEEP

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FETAL BETAMETHASONE EXPOSURE ATTENUATES ANGIOTENSIN-(1-7)-MAS RECEPTOR EXPRESSION IN THE DORSAL MEDULLA OF ADULT SHEEP

Content Provider	PubMed Central
Author	Marshall, Allyson C. Shaltout, Hossam A. Nautiyal, Manisha Rose, James C. Chappell, Mark C. Diz, Debra I.
Copyright Year	2013
Abstract	Glucocorticoids including betamethasone (BM) are routinely administered to women entering into early preterm labor to facilitate fetal lung development and decrease infant mortality; however, fetal steroid exposure may lead to deleterious long term consequences. In a sheep model of fetal programming, BM-exposed (BMX) offspring exhibit elevated mean arterial pressure (MAP) and decreased baroreflex sensitivity (BRS) for control of heart rate by 0.5-years of age associated with changes in the circulating and renal renin-angiotensin systems (RAS). In the brain solitary tract nucleus, angiotensin (Ang) II actions through the AT1 receptor oppose the beneficial actions of Ang-(1-7) at the Mas receptor for BRS regulation. Therefore, we examined Ang peptides, angiotensinogen (Aogen), and receptor expression in this brain region of exposed and control offspring of 0.5- and 1.8-years of age. Mas protein expression was significantly lower (>40%) in the dorsal medulla of BMX animals at both ages; however, AT1 receptor expression was not changed. BMX offspring exhibited a higher ratio of Ang II to Ang-(1-7) (2.30 ± 0.36 versus 0.99 ± 0.28; p<0.01) and Ang II to Ang I at 0.5-years. Although total Aogen was unchanged, Ang I-intact Aogen was lower in 0.5-year BMX animals (0.78 ± 0.06 vs. 1.94 ± 0.41; p<0.05) suggesting a greater degree of enzymatic processing of the precursor protein in exposed animals. We conclude that in utero BM exposure promotes an imbalance in the central RAS pathways of Ang II and Ang-(1-7) that may contribute to the elevated MAP and lower BRS in this model.
Related Links	http://dx.doi.org/10.1016/j.peptides.2013.03.018
Ending Page	31
Page Count	7
Starting Page	25
File Format	PDF
ISSN	01969781
e-ISSN	18735169
Journal	Peptides
Volume Number	44
Language	English
Publisher Date	2013-06-01
Access Restriction	Open
Subject Keyword	Biochemistry Physiology Endocrinology Cellular and Molecular Neuroscience Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Biochemistry Cellular and Molecular Neuroscience Endocrinology

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FETAL BETAMETHASONE EXPOSURE ATTENUATES ANGIOTENSIN-(1-7)-MAS RECEPTOR EXPRESSION IN THE DORSAL MEDULLA OF ADULT SHEEP