NDLI: Induction of plasma protein secretion in a newly established human hepatoma cell line.

Content Provider	PubMed Central
Author	Chang, C. Lin, Y. O-lee, T. W. Chou, C. K. Lee, T. S. Liu, T. J. P'eng, F. K. Chen, T. Y. Hu, C. P.
Abstract	To study the expression and the regulation of hepatocyte markers, we have undertaken to establish human hepatoma cell lines of various phenotypes. We now report the establishment of a new human hepatoma cell line, HA22T/VGH. This cell line has many of the properties of human hepatocellular carcinoma. Only 5 of 15 plasma proteins investigated were detected in the medium of a 10-day-old HA22T/VGH culture. However, when the HA22T/VGH cells and a clonal derivative, C5, were cultured in an aggregated form, all 15 plasma proteins were found in the culture medium. These results indicate that hepatoma cell lines with different phenotypes can be established, and they provide a good experimental framework to investigate differentiation of human hepatocytes.
Starting Page	1133
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	6
Volume Number	3
Language	English
Publisher Date	1983-06-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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Induction of plasma protein secretion in a newly established human hepatoma cell line.