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| Content Provider | PubMed Central |
|---|---|
| Author | Utepbergenov, Darkhan Derewenda, Zygmunt S. |
| Abstract | All known protein kinases share a bilobal kinase domain with well conserved structural elements. Because of significant structural similarities of nucleotide binding pocket, the development of highly selective kinase inhibitors is a very challenging task. Flavonols, naturally occurring plant metabolites, have long been known to inhibit kinases by mimicking the adenine moiety. Interestingly, recent data show that some flavonol glycosides are more selective, although underlying mechanisms were unknown. Crystallographic data from our laboratory revealed that the N-terminal kinase domain of p90 ribosomal S6 kinase, isoform 2, binds three different flavonol rhamnosides in a highly unusual manner, distinct from other kinase inhibitor interactions. The kinase domain undergoes a reorganization of several structural elements in response to the binding of the inhibitors. Specifically, the main β-sheet of the N-lobe undergoes a twisting rotation by ~56° around an axis passing through the N- and C-lobes, leading to the restructuring of the canonical ATP-binding pocket into pockets sterically adapted to the inhibitor shape. The flavonol rhamnosides appear to adopt compact, but strained conformations with the rhamnose moiety swept under the B-ring of flavonol, unlike the structure of the free counterparts in solution. These data suggest that the flavonol glycoside scaffold could be used as a template for new inhibitors selective for the RSK family. |
| Related Links | http://dx.doi.org/10.1016/j.bbapap.2013.03.018 |
| Ending Page | 1291 |
| Page Count | 7 |
| Starting Page | 1285 |
| File Format | |
| ISSN | 15709639 |
| Journal | Biochimica et biophysica acta |
| Issue Number | 7 |
| Volume Number | 1834 |
| Language | English |
| Publisher Date | 2013-07-01 |
| Access Restriction | Open |
| Subject Keyword | Biophysics Analytical Chemistry Biochemistry Molecular Biology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Molecular Biology Biochemistry Biophysics |
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