NDLI: Differential regulation of synaptic transmission by pre- and postsynaptic SK channels in the spinal locomotor network

Content Provider	PubMed Central
Author	Nanou, Evanthia Alpert, Michael H. Alford, Simon El, Manira Abdeljabbar
Copyright Year	2013
Abstract	The generation of activity in the central nervous system requires precise tuning of cellular properties and synaptic transmission. Neural networks in the spinal cord produce coordinated locomotor movements. Synapses in these networks need to be equipped with multiple mechanisms that regulate their operation over varying regimes to produce locomotor activity at different frequencies. Using the in vitro lamprey spinal cord, we explored whether Ca2+ influx via different routes in postsynaptic soma and dendrites and in presynaptic terminals can activate apamin-sensitive Ca2+-activated K+ (SK) channels and thereby shape synaptic transmission. We show that postsynaptic SK channels are tightly coupled to Ca2+ influx via NMDA receptors. Activation of these channels by synaptically induced NMDA-dependent Ca2+ transients restrains the time course of the synaptic current and the amplitude of the synaptic potential. In addition, presynaptic SK channels are activated by Ca2+ influx via voltage-gated channels and control the waveform of the action potential and the resulting Ca2+ dynamics in the axon terminals. The coupling of SK channels to different Ca2+ sources, pre- and postsynaptically, acts as a negative feedback mechanism to shape synaptic transmission. Thus SK channels can play a pivotal role in setting the dynamic range of synapses and enabling short-term plasticity in the spinal locomotor network.
Related Links	http://dx.doi.org/10.1152/jn.00067.2013
Ending Page	3059
Page Count	9
Starting Page	3051
File Format	PDF
ISSN	00223077
e-ISSN	15221598
Journal	Journal of Neurophysiology
Issue Number	12
Volume Number	109
Language	English
Publisher	American Physiological Society
Publisher Date	2013-06-15
Access Restriction	Open
Rights Holder	American Physiological Society
Subject Keyword	Physiology Neuroscience(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

M1 Muscarinic Receptors Boost Synaptic Potentials and Calcium Influx in Dendritic Spines by Inhibiting Postsynaptic SK channels

Differential Roles of Postsynaptic Density-93 Isoforms in Regulating Synaptic Transmission

Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels

Dopaminergic modulation of locomotor network activity in the neonatal mouse spinal cord

Kv1.3 channels regulate synaptic transmission in the nucleus of solitary tract

Presynaptic and Postsynaptic NMDA Receptors Mediate Distinct Effects of Brain-Derived Neurotrophic Factor on Synaptic Transmission

The Extracellular Matrix Molecule Hyaluronic Acid Regulates Hippocampal Synaptic Plasticity by Modulating Postsynaptic L-Type Ca2+ Channels

The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus

Differential Modulation of Synaptic Strength and Timing Regulate Synaptic Efficacy in a Motor Network

Differential regulation of synaptic transmission by pre- and postsynaptic SK channels in the spinal locomotor network

Similar Documents

M1 Muscarinic Receptors Boost Synaptic Potentials and Calcium Influx in Dendritic Spines by Inhibiting Postsynaptic SK channels

Differential Roles of Postsynaptic Density-93 Isoforms in Regulating Synaptic Transmission

Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels

Dopaminergic modulation of locomotor network activity in the neonatal mouse spinal cord

Kv1.3 channels regulate synaptic transmission in the nucleus of solitary tract

Presynaptic and Postsynaptic NMDA Receptors Mediate Distinct Effects of Brain-Derived Neurotrophic Factor on Synaptic Transmission

The Extracellular Matrix Molecule Hyaluronic Acid Regulates Hippocampal Synaptic Plasticity by Modulating Postsynaptic L-Type Ca2+ Channels

The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus

Differential Modulation of Synaptic Strength and Timing Regulate Synaptic Efficacy in a Motor Network

Differential regulation of synaptic transmission by pre- and postsynaptic SK channels in the spinal locomotor network