NDLI: c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore.

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Isolation of the human gene that complements a temperature-sensitive cell cycle mutation in BHK cells.

Nature and specificity of lymphokine independence induced by a selectable retroviral vector expressing v-src.

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In vitro splicing pathways of pre-mRNAs containing multiple intervening sequences?

Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes.

Interaction of GAL4 and GAL80 gene regulatory proteins in vitro.

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The two gene pairs encoding H2A and H2B play different roles in the Saccharomyces cerevisiae life cycle.

Purification of the c-fos enhancer-binding protein.

c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore.

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Differential effectiveness of yeast cytochrome c oxidase subunit genes results from differences in expression not function.

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Intermolecular homologous recombination between transfected sequences in mammalian cells is primarily nonconservative.

Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae.

Metal-dependent binding of a factor in vivo to the metal-responsive elements of the metallothionein 1 gene promoter.

Transformation of NIH 3T3 cells by cotransfection with c-src and nuclear oncogenes.

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Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation.

Guanine analog-induced differentiation of human promyelocytic leukemia cells and changes in queuine modification of tRNA.

Expression of the Aplysia californica rho gene in Escherichia coli: purification and characterization of its encoded p21 product.

Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.

Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae.

Multiple basal elements of a human hsp70 promoter function differently in human and rodent cell lines.

Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines.

Regulation of histone and beta A-globin gene expression during differentiation of chicken erythroid cells.

Identification of the gene for the yeast ribonucleotide reductase small subunit and its inducibility by methyl methanesulfonate.

Immunofluorescence localization of the Saccharomyces cerevisiae CDC12 gene product to the vicinity of the 10-nm filaments in the mother-bud neck.

Differential accumulation of poly(A)+ RNA between virulent and double-stranded RNA-induced hypovirulent strains of Cryphonectria (Endothia) parasitica.

DNA sequence requirements for replication of polyomavirus DNA in vivo and in vitro.

Identification and characterization of functional genes encoding the mouse major urinary proteins.

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Genomic characterization of a gamma-interferon-inducible gene (IP-10) and identification of an interferon-inducible hypersensitive site.

Independent 5' and 3'-end determination of multiple dihydrofolate reductase transcripts.

Regulation of albumin gene expression in a series of rat hepatocyte cell lines immortalized by simian virus 40 and maintained in chemically defined medium.

Tissue-specific and hormonally regulated expression of a rat alpha 2u globulin gene in transgenic mice.

Phorbol ester enhances human immunodeficiency virus-promoted gene expression and acts on a repeated 10-base-pair functional enhancer element.

A cloned human ribosomal protein gene functions in rodent cells.

Proviral sequences that restrict retroviral expression in mouse embryonal carcinoma cells.

Sequences required for transcriptional initiation of the Saccharomyces cerevisiae CYC7 genes.

Domains of beta-tubulin essential for conserved functions in vivo.

Insertions of up to 17 amino acids into a region of alpha-tubulin do not disrupt function in vivo.

The abundance and in vitro DNA binding of three cellular proteins interacting with the adenovirus EIIa early promoter are not modified by the EIa gene products.

Regulation by the yeast mating-type locus of STE12, a gene required for cell-type-specific expression.

A nuclease-hypersensitive region forms de novo after chromosome replication.

Developmentally regulated expression of a truncated myosin light-chain 1F/3F gene.

Transient expression of the beta interferon promoter in human cells.

Murine Hox-1.7 homeo-box gene: cloning, chromosomal location, and expression.

Posttranslational translocation of influenza virus hemagglutinin across microsomal membranes.

Induction of cell cycle progression by adenovirus E1A gene 13S- and 12S-mRNA products in quiescent rat cells.

H5 gene specific trans-activation by nuclear extracts from avian erythroid cells.

The activation of adenylate cyclase by guanyl nucleotides in Saccharomyces cerevisiae is controlled by the CDC25 start gene product.

Expression of the Affected Aγ Globin Gene Associated with Greek Nondeletion Hereditary Persistence of Fetal Hemoglobin

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c-fos sequence necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate and the calcium ionophore.

Content Provider	PubMed Central
Author	Fisch, T. M. Prywes, R. Roeder, R. G.
Abstract	We have investigated the sequence requirements for induction of the human c-fos gene by epidermal growth factor (EGF), 12-O-tetradecanoyl-13-acetate (TPA), and the calcium ionophore A23187 by transfecting c-fos promoter mutants into HeLa and A431 cells. Induction by both EGF and TPA in HeLa cells required the presence of the c-fos enhancer located at -317 to -298 relative to the mRNA cap site. A23187, however, did not induce expression of the transfected gene, even though it strongly induced expression of the endogenous gene, suggesting that it has different requirements for induction than do EGF and TPA. We have also investigated the role of promoter sequences downstream of the enhancer in general expression and induction of c-fos. A sequence between -97 and -76, which includes an 8-base-pair perfect direct repeat, was needed for efficient general expression but not for induction of the gene. A factor in nuclear extracts that bound specifically to this sequence was detected by a gel mobility shift assay. A 7-base-pair sequence, located between -63 and -57 relative to the mRNA cap site and previously shown to be important for general expression of mouse c-fos, was also important for general expression of the human gene. In addition, this element was important for inducibility by EGF and TPA, since induction was significantly reduced when internal deletion mutants that retained the enhancer but lacked the -63 to -57 sequence element were analyzed in transfecting assays.
Starting Page	3490
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	10
Volume Number	7
Language	English
Publisher Date	1987-10-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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