NDLI: Tractography - where do we go from here?

Content Provider	PubMed Central
Author	Saad, Jbabdi Heidi, Johansen-berg
Abstract	Diffusion tractography offers enormous potential for the study of human brain anatomy. However, as a method to study brain connectivity, tractography suffers from limitations, as it is indirect, inaccurate, and difficult to quantify. Despite these limitations, appropriate use of tractography can be a powerful means to address certain questions. In addition, while some of tractography’s limitations are fundamental, others could be alleviated by methodological and technological advances. This article provides an overview of diffusion MR tractography methods with a focus on how future advances might address challenges in measuring brain connectivity. Parts of this review are somewhat provocative, in the hope that they may trigger discussions possibly lacking in a field where the apparent simplicity of the methods (compared to their FMRI counterparts) can hide some fundamental issues that ultimately hinder the interpretation of findings, and cast doubt as to what tractography can really teach us about human brain anatomy.
Related Links	http://dx.doi.org/10.1089/brain.2011.0033
Ending Page	183
Page Count	15
Starting Page	169
File Format	PDF
ISSN	21580014
e-ISSN	21580022
Journal	Brain connectivity
Issue Number	3
Volume Number	1
Language	English
Publisher Date	2011-09-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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Tractography - where do we go from here?