NDLI: Modeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer

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Modeling and experiments of magneto-nanosensors for diagnostics of radiation exposure and cancer

Content Provider	PubMed Central
Author	Kim, Dokyoon Lee, Jung-rok Shen, Eric Wang, Shan X.
Copyright Year	2012
Abstract	We present a resistive network model, protein assay data, and outlook of the giant magnetoresistive (GMR) spin-valve magneto-nanosensor platform ideal for multiplexed detection of protein biomarkers in solutions. The magneto-nanosensors are designed to have optimal performance considering several factors such as sensor dimension, shape anisotropy, and magnetic nanoparticle tags. The resistive network model indicates that thinner spin-valve sensors with narrower width lead to higher signals from magnetic nanoparticle tags. Standard curves and real-time measurements showed a sensitivity of ~10 pM for phosphorylated-structural maintenance of chromosome 1 (phosphor-SMC1), ~53 fM for granulocyte colony stimulation factor (GCSF), and ~460 fM for interleukin-6 (IL6), which are among the representative biomarkers for radiation exposure and cancer.
Related Links	http://dx.doi.org/10.1007/s10544-012-9678-z
Ending Page	671
Page Count	7
Starting Page	665
File Format	PDF
ISSN	13872176
e-ISSN	15728781
Journal	Biomedical microdevices
Issue Number	4
Volume Number	15
Language	English
Publisher Date	2013-08-01
Access Restriction	Open
Subject Keyword	Molecular Biology Biomedical Engineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Molecular Biology Biomedical Engineering

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