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| Content Provider | PubMed Central |
|---|---|
| Author | Luo, Xiaobing Ranade, Koustubh Talker, Ronel Jallal, Bahija Shen, Nan Yao, Yihong |
| Copyright Year | 2013 |
| Abstract | miRNAs have been shown to play essential regulatory roles in the innate immune system. They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the expression of their target proteins, preferentially crucial signaling components and transcription factors. Studies in humans and in disease models have revealed that dysregulation of several miRNAs such as miR-146a and miR-155 in rheumatic diseases leads to aberrant production of and/or signaling by inflammatory cytokines and, thus, critically contributes to disease pathogenesis. In addition, the recent description of the role of certain extracellular miRNAs as innate immune agonist to induce inflammatory response would have direct relevance to rheumatic diseases. |
| Related Links | http://dx.doi.org/10.1186/ar4194 |
| Ending Page | 210 |
| Page Count | 1 |
| Starting Page | 210 |
| File Format | |
| ISSN | 14786362 |
| e-ISSN | 14786362 |
| Journal | Arthritis Research & Therapy |
| Issue Number | 2 |
| Volume Number | 15 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Rights Holder | BioMed Central |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology Rheumatology |
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