Loading...
Please wait, while we are loading the content...
Similar Documents
Assessing the efficacy of 2 years of maintenance treatment with venlafaxine extended release 75–225 mg/day in patients with recurrent major depression: a secondary analysis of data from the PREVENT study
| Content Provider | PubMed Central |
|---|---|
| Author | Kornstein, Susan G. Kocsis, James H. Ahmed, Saeeduddin Michael, Thase Friedman, Edward S. Dunlop, Boadie W. Yan, Bing Pedersen, Ron Ninan, Philip T. Thomas, Li Keller, Martin |
| Copyright Year | 2008 |
| Abstract | The objective of this study was to evaluate the long-term efficacy of venlafaxine extended release (ER) ≤225 mg/ day in patients with recurrent major depressive disorder (MDD). In this double-blind trial, outpatients with recurrent MDD (N=1096) were randomized to 10 weeks of acute-phase treatment with venlafaxine ER (75–300 mg/ day) or fluoxetine (20–60 mg/day) followed by a 6-month continuation phase and two consecutive 12-month maintenance phases. At the start of each maintenance period, venlafaxine ER responders were randomized to double-blind venlafaxine ER or placebo. In this analysis, data from responders to acute and continuation treatment were analyzed during the combined maintenance phases while receiving venlafaxine ER ≤225 mg/day. Failure to maintain response was defined as an increase in maintenance dose to 300 mg/day or recurrence. Differences were calculated using Kaplan–Meier methods and compared using log-rank tests. Continuation-phase responders (n =114) receiving venlafaxine ER ≤225 mg/ day comprised the analysis population (venlafaxine ER: n= 55; placebo: n= 59). The estimated probability for remaining well across 24 months of maintenance treatment was 67% for venlafaxine ER and 41% for placebo (P = 0.007). Venlafaxine ER effectively maintained response at doses ≤225 mg/day for up to 2.5 years in patients with recurrent MDD. The findings are consistent with those of the full data set. |
| Related Links | http://dx.doi.org/10.1097/YIC.0b013e328314e2cb |
| Ending Page | 363 |
| Page Count | 7 |
| Starting Page | 357 |
| File Format | |
| ISSN | 14735857 |
| e-ISSN | 14735857 |
| Journal | International clinical psychopharmacology |
| Issue Number | 6 |
| Volume Number | 23 |
| Language | English |
| Publisher Date | 2008-11-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Psychiatry and Mental Health |
