NDLI: Innate immune response after adenoviral gene delivery into skin is mediated by AIM2, NALP3, DAI and mda5

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Year: 2016, Volume: 5

Year: 2015, Volume: 4

Year: 2014, Volume: 3

Year: 2013, Volume: 2

Year: 2013, Volume: 2, Issue: Unspecified

Diagnostic value of triple-phase bone scintigraphy for the diagnosis of infection around antibiotic-impregnated cement spacers

Gene expression profiling of the anti-glioma effect of Cilengitide

Electromyographic responses during time get up and go test in water (wTUG)

Enhanced glycemic control, pancreas protective, antioxidant and hepatoprotective effects by umbelliferon-α-D-glucopyranosyl-(2I → 1II)-α-D-glucopyranoside in streptozotocin induced diabetic rats

Histological assessments of intestinal immuno-morphology of tiger grouper juvenile, Epinephelus fuscoguttatus

Comparison of clinical features and outcomes of staphylococcus aureus vertebral osteomyelitis caused by methicillin-resistant and methicillin-sensitive strains

Foraging of Psilocybe basidiocarps by the leaf-cutting ant Acromyrmex lobicornis in Santa Fé, Argentina

Algorithm for shortest path search in Geographic Information Systems by using reduced graphs

Acinetobacter baumannii producing OXA-23 detected in the Czech Republic

How to explain exercise-induced phenotype from molecular data: rethink and reconstruction based on AMPK and mTOR signaling

Analysis of 10 km swimming performance of elite male and female open-water swimmers

Empiric mathematical model for predicting the content of alpha-acids in hop (Humulus lupulus L.) cv. Aurora

Interactive network analysis of the plasma amino acids profile in a mouse model of hyperglycemia

Retrieval of HPV oncogenes E6 and E7 mRNA from cervical specimens using a manual open technology protocol

Long-term, up to 18 months, protective effects of the angiotensin II receptor blocker telmisartan on Epirubin-induced inflammation and oxidative stress assessed by serial strain rate

Evaluation of sweet potato for fuel bioethanol production: hydrolysis and fermentation

Proteolytic enzymes from Bromelia antiacantha as tools for controlled tissue hydrolysis in entomology

Brief migraine episodes in children and adolescents-a modification to International Headache Society pediatric migraine (without aura) diagnostic criteria

hTERT promoter polymorphism, -1327C>T, is associated with the risk of epithelial cancer

Anthocyanin-rich Aronia melanocarpa extract improves body temperature maintenance in healthy women with a cold constitution

Psychrotrophic Pseudomonas mandelii CBS-1 produces high levels of poly-β-hydroxybutyrate

Serum anti-P53 antibodies and alpha-fetoprotein in patients with non-B non-C hepatocellular carcinoma

Sudden weaning of angel fish pterophyllum scalare (Lichtenstein) (Pisces; Cichlidae) larvae from brine shrimp (Artemia sp) nauplii to formulated larval feed

New pulse wave measurement method using different hold-down wrist pressures according to individual patient characteristics

Activity of hypertonic solution with Silver and Potassium Sucrose Octasulfate on nasal symptoms in obstructive rhinopathy with and without rhinosinusitis

Fulvestrant up regulates UGT1A4 and MRPs through ERα and c-Myb pathways: a possible primary drug disposition mechanism

Searching and generating test inputs for mutation testing

Establishing a trauma registry in Bhutan: needs and process

Reduction in weight and BMI and changes in Co-morbidities following laparoscopic adjustable gastric banding procedure for morbidly obese patients in Bahrain: a five year longitudinal study

FDG-PET/CT of sarcoidosis and sarcoid reactions following antineoplastic treatment

Generation and selection of anti-flagellin monoclonal antibodies useful for serotyping Salmonella enterica

A review method for UML requirements analysis model employing system-side prototyping

Trade-offs in quality of life and survival with chemotherapy for advanced breast cancer: mature results of a randomized trial comparing single-agent mitoxantrone with combination cyclophosphamide, methotrexate, 5-fluorouracil and prednisone

Reclassification of the Fuhrman grading system in renal cell carcinoma-does it make a difference?

A case report of human immunodeficiency virus-associated anaplastic lymphoma kinase protein-negative anaplastic large cell lymphoma

Hyperglycaemia and oxidative stress upregulate HSP60 & HSP70 expression in HeLa cells

Euthanasia tactics: patterns of injustice and outrage

Adoption of radio-frequency identification to establish traceability in Taiwanese eel exported to the Japanese market

Identification of harmful cyanobacteria in the Sacramento-San Joaquin Delta and Clear Lake, California by DNA barcoding

Long-term dynamics of hematological data and spleen volume in cirrhotic patients after liver transplantation-various dynamics depending on etiology

Comparison of a quantitative real-time polymerase chain reaction (qPCR) with conventional PCR, bacterial culture and ELISA for detection of Mycobacterium avium subsp. paratuberculosis infection in sheep showing pathology of Johne’s disease

Spectrum analysis on quality requirements consideration in software design documents

Panax ginseng extract rich in ginsenoside protopanaxatriol offers combinatorial effects in nitric oxide production via multiple signaling pathways

Expected for acquisition movement exercise is more effective for functional recovery than simple exercise in a rat model of hemiplegia

Direct observation of cell cycle progression in living mouse embryonic stem cells on an extracellular matrix of E-cadherin

Influence of body mass index on Benign Prostatic Hyperplasia-related complications in patients undergoing prostatectomy

Efficient material flow in mixed model assembly lines

The effect of tea fermentation on rosmarinic acid and antioxidant properties using selected in vitro sprout culture of Orthosiphon aristatus as a model study

Comparison result of inversion of gravity data of a fault by particle swarm optimization and Levenberg-Marquardt methods

An audit to determine if vitamin b12 supplementation is necessary after sleeve gastrectomy

Occurrence of macrophyte monocultures in drainage ditches relates to phosphorus in both sediment and water

Impact of freezing rate on electrical conductivity of produce

Mitigation of salt stress in wheat seedlings by halotolerant bacteria isolated from saline habitats

Seasonal variations of EPG Levels in gastro-intestinal parasitic infection in a southeast asian controlled locale: a statistical analysis

Enzymatic activity of Lactobacillus reuteri grown in a sweet potato based medium with the addition of metal ions

A statistical approach to quantitative data validation focused on the assessment of students’ perceptions about biotechnology

Mutant LV476-7AA of A-subunit of Enterococcus hirae V1-ATPase: High affinity of A3B3 complex to DF axis and low ATPase activity

Using Bacillus amyloliquefaciens for remediation of aquaculture water

Cardiorespiratory fitness in breast cancer survivors

Carotid Wallstent placement difficulties encountered in carotid artery stenting

Predictive impact of polymorphism of PNPLA3 on HCC development after interferon therapy in Japanese patients with chronic hepatitis C

Virtual screening for oseltamivir-resistant a (H5N1) influenza neuraminidase from traditional Chinese medicine database: a combined molecular docking with molecular dynamics approach

Analysis of recycled poly (styrene-co-butadiene) sulfonation: a new approach in solid catalysts for biodiesel production

Experimental study on tourist satisfaction using participatory simulation in a virtual environment

Identification of a Histidine Metal Ligand in the argE-Encoded N-Acetyl-L-Ornithine Deacetylase from Escherichia coli

Natural radioactivity levels of some medicinal plants commonly used in Ghana

Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India

Rooting and acclimatization of micropropagated marubakaido apple rootstock using Adesmia latifolia rhizobia

Effect of rain gauge density over the accuracy of rainfall: a case study over Bangalore, India

Unconscious learning processes: mental integration of verbal and pictorial instructional materials

Linking phylogeny to abundant ribotypes of community fingerprints: an exercise on the phylotypic responses to plant species, fertilisation and Lolium perenne ingression

Contribution of extrahepatic small cells resembling small hepatocyte-like progenitor cells to liver mass maintenance in transplantation model of retrorsine-pretreated liver

Information literacy of U.S. and Indian engineering undergraduates

Optimal multiobjective design of digital filters using spiral optimization technique

Osteoprotegerin (OPG) as a biomarker for diabetic cardiovascular complications

Physiological and morphological responses of Lead or Cadmium exposed Chlorella sorokiniana 211-8K (Chlorophyceae)

Polyvinyl alcohol:starch:carboxymethyl cellulose containing sodium montmorillonite clay blends; mechanical properties and biodegradation behavior

Rare case of malignant transformation of recurrent respiratory papillomatosis associated with human papillomavirus type 6 infection and p53 overexpression

Genetic structure and diversity of indigenous rice (Oryza sativa) varieties in the Eastern Himalayan region of Northeast India

Impact of an early education multimedia intervention in managing nutrition-related chemotherapy side effects: a pilot study

Purification and identification of trichloroethylene induced proteins from Stenotrophomonas maltophilia PM102 by immuno-affinity-chromatography and MALDI-TOF Mass spectrometry

Influence of cheek support on respiratory impedance measured by forced oscillation technique

Critical elements in implementations of just-in-time management: empirical study of cement industry in Pakistan

Measuring quality in diabetes care: an expert-based statistical approach

Skin rash by gefitinib is a sign of favorable outcomes for patients of advanced lung adenocarcinoma in Japanese patients

Initial serum sodium concentration determines the decrease in sodium level after terlipressin administration in patients with liver cirrhosis

Production, purification and characterization of a novel thermotolerant endoglucanase (CMCase) from Bacillus strain isolated from cow dung

Creation of a synthetic indicator of quality of care as a clinical management standard in primary care

Study the seasonal steroid hormones of common carp in Caspian Sea, Iran

Root biomass and soil carbon distribution in hybrid poplar riparian buffers, herbaceous riparian buffers and natural riparian woodlots on farmland

Adjunctive imprint cytology of core needle biopsy specimens improved diagnostic accuracy for breast cancer

Utility of two novel multiplexing assays for the detection of gastrointestinal pathogens – a first experience

Performance in Olympic triathlon: changes in performance of elite female and male triathletes in the ITU World Triathlon Series from 2009 to 2012

The potential impact of adding genetic markers to clinical parameters in managing high-risk prostate cancer patients

Assessment of heavy metal (Cu, Ni, Fe, Co, Mn, Cr, Zn) pollution in effluent dominated rivulet water and their effect on glycogen metabolism and histology of Mastacembelus armatus

Flat-pressed wood plastic composites from sawdust and recycled polyethylene terephthalate (PET): physical and mechanical properties

Principled missing data methods for researchers

Negative expression of N-acetylglucosaminyltransferase V in oral squamous cell carcinoma correlates with poor prognosis

Comparison of adaptive neuro-fuzzy inference system and artificial neutral networks model to categorize patients in the emergency department

Barriers and facilitators to self-care in chronic heart failure: a meta-synthesis of qualitative studies

Life history and assessment of grapevine phylloxera leaf galling incidence on Vitis species in Uruguay

Identification of thermo tolerant lactic acid bacteria isolated from silage prepared in the hot and humid climate of Southwestern Japan

Oxidation of tricyclic antidepressant drugs with chloramine-T in acidic solutions: kinetic, mechanistic and thermodynamic studies

Developmental variation and the evolution of distyly in Hedyotis caerulea (Rubiaceae)

Clinical characteristics of pain originating from intra-articular structures of the knee joint in patients with medial knee osteoarthritis

Use of the kidney injury molecule-1 as a biomarker for early detection of renal tubular dysfunction in a population chronically exposed to cadmium in the environment

Characterizing inflammatory breast cancer among Arab Americans in the California, Detroit and New Jersey Surveillance, Epidemiology and End Results (SEER) registries (1988–2008)

Concentration dependent Electrospray Ionisation Mass Spectrometry and Tandem Mass Spectrometry (MS/MS ) studies on (E,E)-1-[5-(1,3-benzodioxol-5yl)-1-oxo-2,4-pentadienyl]- piperidine (Piperine) and its analogues

Magnetostatic surface waves propagation at dissipative ferrite-MTMs-metal structure

Percutaneous transluminal renal angioplasty with stenting for stenotic venous bypass grafts: report of two cases

Integrin triplets of marine sponges in the murine and human MHCI-CD8 interface and in the interface of human neural receptor heteromers and subunits

Exact traveling wave solutions of the KP-BBM equation by using the new approach of generalized (G′/G)-expansion method

Trial encoding algorithms ensemble

Syntheses, characterizations and thermal analyses of four novel unsymmetrical β-diketiminates

Hip structural analysis: a comparison of DXA with CT in postmenopausal Japanese women

Changes in serum BDNF levels associated with moderate-intensity exercise in healthy young Japanese men

An unusual case report on the possible role of Warfarin in migraine prophylaxis

Time to definitive diagnosis of breast cancer in Latina and non-Hispanic white women: the six cities study

The prevalence of platelet activating factor acetylhydrolase single nucleotide polymorphisms in relationship to necrotizing enterocolitis in Northwest Louisiana infants

Modeling and prediction of cytotoxicity of artemisinin for treatment of the breast cancer by using artificial neural networks

Cash efficiency for bank branches

Lying down with protective setae as an alternative antipredator defence in a non-webbing spider mite

Is emphysema a risk factor for pneumothorax in CT-guided lung biopsy?

Neurodevelopmental outcomes of moderately preterm birth: precursors of attention deficit hyperactivity disorder at preschool age

Detection and control of Ganoderma boninense: strategies and perspectives

Controlled root targeted delivery of fertilizer using an ionically crosslinked carboxymethyl cellulose hydrogel matrix

Factors associated with wait times across the breast cancer treatment pathway in Ontario

p31comet inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs

The importance of rapid aneuploidy screening and prenatal diagnosis in the detection of numerical chromosomal abnormalities

Novel xylanases from Simplicillium obclavatum MTCC 9604: comparative analysis of production, purification and characterization of enzyme from submerged and solid state fermentation

A Japanese neonatal case of glucose-6-phosphate dehydrogenase deficiency presenting as severe jaundice and hemolytic anemia without apparent trigger

Bladder cancer discussed on the internet: a systematic analysis of gender differences of initial posters on an online discussion board

Experimental measurement of tympanic membrane response for finite element model validation of a human middle ear

Biochemical and histopathological study in rats intoxicated with carbontetrachloride and treated with camel milk

Ecology of an endemic primate species (Macaca siberu) on Siberut Island, Indonesia

Preventive effect of cyproheptadine hydrochloride in refractory patients with frequent migraine

Perihematomal glutamate level is associated with the blood–brain barrier disruption in a rabbit model of intracerebral hemorrhage

Jump exercise during hindlimb unloading protect against the deterioration of trabecular bone microarchitecture in growing young rats

A collaborative working environment for small group meetings in Second Life

Suitability analysis for rice growing sites using a multicriteria evaluation and GIS approach in great Mwea region, Kenya

Incretin secretion stimulated by ursodeoxycholic acid in healthy subjects

The method to divide a sentence of requirement into individual requirements and the development of requirement specification editor which can describe individual requirements

Invasive ductolobular carcinoma of the breast: spectrum of mammographic, ultrasound and magnetic resonance imaging findings correlated with proportion of the lobular component

Improvement of somatic embryogenesis and plantlet conversion in Oplopanax elatus, an endangered medicinal woody plant

Rapid and sensitive detection of bla KPC gene in clinical isolates of Klebsiella pneumoniae by a molecular real-time assay

Cluster headache associated with acute maxillary sinusitis

Associations between null mutations in GSTT1 and GSTM1, the GSTP1 Ile105Val polymorphism, and mortality in breast cancer survivors

Design and optimization of ethanol production from bagasse pith hydrolysate by a thermotolerant yeast Kluyveromyces sp. IIPE453 using response surface methodology

Tuberculosis examination using whole blood interferon-gamma release assay among health care workers in a Japanese hospital without tuberculosis-specific wards

Hand disease in scleroderma: a clinical correlate for chronic hand transplant rejection

Investigations on juvenile fish excluder cum shrimp sorting device (JFE-SSD)

Development, inheritance and breeding potential of a recessive genic male sterile line D248A in Sesame (Sesamum indicum L.)

Interleukin-6: a potent biomarker of mycobacterial infection

Plasmablastic lymphoma of the maxillary sinus in an HIV-negative patient: a case report and literature review

A possible approach for gel-based proteomic studies in recalcitrant woody plants

Hybrid poplar plantations are suitable habitat for reintroduced forest herbs with conservation status

Impact of alternative approaches to assess outlying and influential observations on health care costs

EEG-based analysis of human driving performance in turning left and right using Hopfield neural network

Parenteral administration of twin-bearing ewes with L-arginine enhances the birth weight and brown fat stores in sheep

Use of UPLC-ESI-MS/MS to quantitate free amino acid concentrations in micro-samples of mammalian milk

Estimating changes in metabolic power from EMG

Comparison of the body proximate compositions of juvenile bronze gudgeon (Coreius heterodon) and largemouth bronze gudgeon (C. guichenoti) in the upstream region of the Yangtze River

Inhibition of Flavobacterium psychrophilum biofilm formation using a biofilm of the antagonist Pseudomonas fluorescens FF48

Male reproductive traits of full-sibs of different age classes in three-spined sticklebacks (Gasterosteus aculeatus)

Large-scale solar magnetic field mapping: I

Reasons of not having breast reconstruction: a historical cohort of 1937 breast cancer patients undergoing mastectomy

Cystine and theanine: amino acids as oral immunomodulative nutrients

Carbamoylation correlates of cyanate neuropathy and cyanide poisoning: relevance to the biomarkers of cassava cyanogenesis and motor system toxicity

The passage of cells can improve the detection rate of avian leukosis virus to facilitate the elimination of avian leukosis in chickens

Smoking cessation in community pharmacy practice–a clinical information needs analysis

Cost of comprehensive patient assistance program in early breast cancer patients

Determination of radionuclides and elemental composition of clay soils by gamma- and X-ray spectrometry

A knowledge representation approach using fuzzy cognitive maps for better navigation support in an adaptive learning system

High-dose intravenous methylprednisolone for the prophylactic treatment of cluster headache

pKa determination of oxysophocarpine by reversed - phase high performance liquid chromatography

The effects of a formal exercise training programme on salivary hormone concentrations and body composition in previously sedentary aging men

Experimental development based on mapping rule between requirements analysis model and web framework specific design model

Thermodynamic parameters of U (VI) sorption onto soils in aquatic systems

Individual quality of life in patients with multiple myeloma

The combination of Ki67, histological grade and estrogen receptor status identifies a low-risk group among 1,854 chemo-naïve women with N0/N1 primary breast cancer

Human GMDS gene fragment hypermethylation in chronic high level of arsenic exposure with and without arsenic induced cancer

Integrated electronic prescribing and robotic dispensing: a case study

Effect of facial expressions on student’s comprehension recognition in virtual educational environments

Analysis of bortezomib inhibitor docked within the catalytic subunits of the Plasmodium falciparum 20S proteasome

Variability and distribution of spatial evapotranspiration in semi arid Inner Mongolian grasslands from 2002 to 2011

The detection of foodborne bacteria on beef: the application of the electronic nose

Photodegradation and photostabilization of polymers, especially polystyrene: review

The political economy of healthcare reform in China: negotiating public and private

Obstacles encountered during transradial angiography from after Radial Artery puncture to the aortic arch

Efficacy of complete decongestive therapy (CDT) on edematous rat limb after lymphadenectomy demonstrated by real time lymphatic fluid tracing

Molecular cloning and development of RAPD-SCAR markers for Dimocarpus longan variety authentication

A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers

Muscle function and omega-3 fatty acids in the prediction of lean body mass after breast cancer treatment

Stability of the volume of air trapped on the abdomen of the water spider Argyroneta aquatica

Lower limb body composition is associated to knee passive extension torque-angle response

Normal domain temperature profile in second generation HTS tape wire

Relationship between post-exercise heart rate variability and skinfold thickness

Behavior believability in virtual worlds: agents acting when they need to

An assessment of the concentrations of pharmaceutical compounds in wastewater treatment plants on the island of Gran Canaria (Spain)

Investigation of heavy metals in frequently utilized medicinal plants collected from environmentally diverse locations of north western India

SCLpredT: Ab initio and homology-based prediction of subcellular localization by N-to-1 neural networks

Utilisation of Home Laundry Effluent (HLE) as a catalyst for expeditious one-pot aqueous phase synthesis of highly functionalised 4-thiazolidinones

A one-dimensional slope detection approach

Advantages of one step nucleic acid amplification (OSNA) whole node assay in sentinel lymph node (SLN) analysis in breast cancer

Trends in the use of antiasthmatic medications in Morocco (1999–2010)

Non-conventional induction strategies for production of subunit swine erysipelas vaccine antigen in rE. coli fed-batch cultures

Technical efficiency in milk production in underdeveloped production environment of India*

Cold tolerance in Osmotin transgenic tomato (Solanum lycopersicum L.) is associated with modulation in transcript abundance of stress responsive genes

Impact of closed-system drug transfer device on exposure of environment and healthcare provider to cyclophosphamide in Japanese hospital

Muscle free amino acid profiles are related to differences in skeletal muscle growth between single and twin ovine fetuses near term

Complementary pharmacokinetic measures to further define the profile of once-daily OROS hydromorphone ER during single-dose and steady-state dosing

Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism

Cerebral air embolism via port catheter and endoscopic retrograde cholangio-pancreatography

Diversity of fungal flora in raw milk from the Italian Alps in relation to pasture altitude

Effect of active fraction isolated from the leaf extract of Dregea volubilis [Linn.] Benth. on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats

On some properties of the generalized Mittag-Leffler function

A case of synchronous bilateral breast cancer with different pathological responses to neoadjuvant chemotherapy with different biological character

Prediction of the muscle strength by the muscle thickness and hardness using ultrasound muscle hardness meter

Synthesis and characterization of transition metal complexes of 4-Amino-5-pyridyl-4H-1,2,4-triazole-3-thiol

Analysis on genetic diversification and heterosis in autotetraploid rice

Production of schizophyllan from distiller’s dried grains with solubles by diverse strains of Schizophyllum commune

Proliferative effect and osteoinductive potential of extracellular matrix coated on cell culture plates

Discovery of novel plastid phenylalanine (trnF) pseudogenes defines a distinctive clade in Solanaceae

Hierarchical fixed points of strictly pseudo contractive mappings for variational inequality problems

Maternal factors contributing to under-five mortality at birth order 1 to 5 in India: a comprehensive multivariate study

Outcomes of patients with acetaminophen-associated toxic hepatitis at a far east poison center

A rapid analysis of plasma/serum ethylene and propylene glycol by headspace gas chromatography

Cancer resource center of the desert patient navigator program: removing financial barriers to access to cancer care for rural Latinos

Question answering system using Q & A site corpus Query expansion and answer candidate evaluation

Nutrition research in the first decade of 21st century in Iran: the necessity of road Map

Distribution of D-amino acids in vinegars and involvement of lactic acid bacteria in the production of D-amino acids

Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging

Validation of the Enterococci indicator for bacteriological quality monitoring of beaches in Malaysia using a multivariate approach

Can levels of antioxidants in synovial fluid predict the severity of primary knee osteoarthritis: a preliminary study

The melanocyte photosensory system in the human skin

Heterologous expression, immunochemical and computational analysis of recombinant human interferon alpha 2b

Mercury concentration in the eggs of four Canadian Arctic-breeding shorebirds not predicted based on their population statuses

Outcomes research resources in India: current status, need and way forward

Imipenem/cilastatin sodium (IPM/CS) as an embolic agent for transcatheter arterial embolisation: a preliminary clinical study of gastrointestinal bleeding from neoplasms

Comulang: towards a collaborative e-learning system that supports student group modeling

An automated tool for localization of heart sound components S1, S2, S3 and S4 in pulmonary sounds using Hilbert transform and Heron’s formula

Social and ecological challenges of market-oriented shrimp farming in Vietnam

Effect of acute exercise on patella tendon protein synthesis and gene expression

Clinical significance of the sub-classification of 71 cases mucinous breast carcinoma

A novel antifungal protein of Bacillus subtilis B25

A linear programming approach for placement of applicants to academic programs

Image-guided therapy system for interstitial gynecologic brachytherapy in a multimodality operating suite

A review of the recycling of non-metallic fractions of printed circuit boards

Selective head cooling for the treatment of neurologic complications of acute liver failure in a newborn with disseminated herpes infection

Identification of differentially expressed genes in microarray data in a principal component space

Effect of humidity on egg hatchability and reproductive biology of the bamboo borer (Dinoderus minutus Fabricius)

Opportunities for optimization of in-field water harvesting to cope with changing climate in semi-arid smallholder farming areas of Zimbabwe

Use of in-vitro experimental results to model in-situ experiments: bio-denitrification under geological disposal conditions

Optimization of the production and characterization of milk clotting enzymes by Bacillus subtilis natto

Sociomicrobiome of wood decay in a tropical rain forest: unraveling complexity

An optimization method for parameter extraction of metals using modified Debye model

Treatment of Methicillin-resistant Staphylococcus aureus experimental Osteomyelitis with bone-targeted Vancomycin

Clinicopathological features and immunohistochemical detection of antigens in acute experimental Streptococcus agalactiae infection in red tilapia (Oreochromis spp.)

Plant growth-promoting activities of Streptomyces spp. in sorghum and rice

One-stage laparoscopic surgery for inspissated bile syndrome: case report and review of surgical techniques

Atenolol in the prophylaxis of chronic migraine: a 3-month open-label study

Model-based iterative reconstruction for reduction of radiation dose in abdominopelvic CT: comparison to adaptive statistical iterative reconstruction

Redefining ‘Worlds’: the writerly ethics in the trailing temporality of J. M. Coetzee’s Disgrace

Comparison of hospital-wide and age and location - stratified antibiograms of S. aureus, E. coli, and S. pneumoniae: age- and location-stratified antibiograms

Headache after exposure to ‘date-rape’ drugs

VO2 and VCO2 variabilities through indirect calorimetry instrumentation

How Transcranial Doppler can assess the effect of hyperosmolar therapy and the degree of circulatory compromise in acute brain herniation

Temporal and spatial variation in bird and human use of beaches in southern California

Cortical non-aneurysmal subarachnoid hemorrhage post-carotid endarterectomy: a case report and literature review

Phytochemical analysis, antimicrobial and radical-scavenging properties of Acalypha manniana leaves

Therapeutic hypothermia in cerebral air embolism: a case report

Gamma radiation mediated green synthesis of gold nanoparticles using fermented soybean-garlic aqueous extract and their antimicrobial activity

DNA methylation-mediated silencing of PU.1 in leukemia cells resistant to cell differentiation

Activity-based costing in services: literature bibliometric review

Bisphenol A stimulates human prostate cancer cell migration via remodelling of calcium signalling

Ontology in association rules

Epidemiology and acquisition of extended-spectrum beta-lactamase-producing Enterobacteriaceae in a septic orthopedic ward

The addition of bevacizumab to standard chemotherapy in breast cancer: which patient benefits the most?

Autoimmune diseases and hypersensitivities improve the prognosis in ER-negative breast cancer

Macroporous polymer supported azide and nanocopper (I): efficient and reusable reagent and catalyst for multicomponent click synthesis of 1,4-disubstituted-1H-1,2,3-triazoles from benzyl halides

Barriers and challenges in integration of anthroposophic medicine in supportive breast cancer care

Pediatric robotic assisted laparoscopic nephropexy: case study

Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients

Ruminal impaction due to Ficus esquiroliana Levl. in Boer goats

Application of alizarin colorimetric measurements for quantification of amine extraction by model food simulants from epoxy polymer

Edge-interior differences in the species richness and abundance of drosophilids in a semideciduous forest fragment

Immunohistochemical study of pituitary cells in wild and captive Salminus hilarii (Characiformes: Characidae) females during the annual reproductive cycle

An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome-wide association studies

Lack of HLA predominance and HLA shared epitopes in biliary Atresia

The use of mixture model theory in CFD for the chemical reaction between CO2 and soda lime in closed circuit rebreather scrubbers

Conditional QTL mapping for waterlogging tolerance in two RILs populations of wheat

Ecotypic variation for seed dormancy, longevity and germination requirements in wild/weedy Sorghum bicolor in Ethiopia: implications for seed mediated transgene dispersal and persistence

Usability assessment of an electronic health record in a comprehensive dental clinic

Evaluate of heavy metal concentration in shrimp (Penaeus semisulcatus) and crab (Portunus pelagicus) with INAA method

Experimental system for measurement of radiologists’ performance by visual search task

Impact of tumor chronology and tumor biology on lymph node metastasis in breast cancer

Effect of copper sulfate on the survival and growth performance of Caspian Sea kutum, Rutilus frisii kutum

RNA blood levels of osteopontin splice variants are cancer markers

Characterisation of enterovirus 71 replication kinetics in human colorectal cell line, HT29

Stress in farmed saltwater crocodiles (Crocodylus porosus): no difference between individually- and communally-housed animals

Genetic diversity and relationship of cattle populations of East India: distinguishing lesser known cattle populations and established breeds based on STR markers

Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management

Biodiversity baseline of the French Guiana spider fauna

Acetate adaptation of clostridia tyrobutyricum for improved fermentation production of butyrate

Accuracy of axillary ultrasound in preoperative nodal staging of breast cancer - size of metastases as limiting factor

Cropping practices, soil properties, pedotransfer functions and organic carbon storage at Kuanria canal command area in India

Pituitary gland metastasis from rectal cancer: report of a case and literature review

Vehicular emission inventory of criteria pollutants in Delhi

Impaired of a non-DNA dependent methylation status decides the fat decision of bone marrow-derived C3H10T1/2 stem cell

Bias problems in culture-independent analysis of environmental bacterial communities: a representative study on hydrocarbonoclastic bacteria

Identification and bioactive potential of endophytic fungi isolated from selected plants of the Western Himalayas

Small molecules inhibit growth, viability and ergosterol biosynthesis in Candida albicans

Production of HlyA and ClyA haemolysins among quinolone-resistant Escherichia coli isolated from clinical samples

Enhancing nitrilase production from Fusarium proliferatum using response surface methodology

Marinobacter hydrocarbonoclasticus NY-4, a novel denitrifying, moderately halophilic marine bacterium

Pangola grass as forage for ruminant animals: a review

The genetic study utility of a hexaploid wheat DH population with non-recombinant A- and B-genomes

An efficient protocol for total DNA extraction from the members of order Zingiberales- suitable for diverse PCR based downstream applications

Bacterial community composition shifts in the gut of Periplaneta americana fed on different lignocellulosic materials

A reliable and effective method of DNA isolation from old human blood paper cards

Presence of anaplastic lymphoma kinase in inflammatory breast cancer

Molecular characterization of Bacillus thuringiensis using rep-PCR

Effect of dietary fat type on anxiety-like and depression-like behavior in mice

A comparative survey of genetic diversity among a set of Caricaceae accessions using microsatellite markers

Is family-friendly policy (FFP) working in the private sector of South Korea?

Mutational pressure dictates synonymous codon usage in freshwater unicellular α - cyanobacterial descendant Paulinella chromatophora and β - cyanobacterium Synechococcus elongatus PCC6301

Stability and prognostic value of Slug, Sox9 and Sox10 expression in breast cancers treated with neoadjuvant chemotherapy

Antibacterial activities of the methanol extracts of seven Cameroonian dietary plants against bacteria expressing MDR phenotypes

Genetic and non-genetic parameters of replacement rate component traits in Holstein Friesian cattle

Cluster headache and arachnoid cyst

Oryzias melastigma – an effective substitute for exotic larvicidal fishes: enhancement of its reproductive potential by supplementary feeding

Technical accuracy of optical and the electromagnetic tracking systems

How intermittent presentation affects conscious perceptual reversals of ambiguous figures

Bioprocess and biotecnology: effect of xylanase from Aspergillus niger and Aspergillus flavus on pulp biobleaching and enzyme production using agroindustrial residues as substract

Women experience lower postprandial oxidative stress compared to men

Phylogenetic identification of marine bacteria isolated from deep-sea sediments of the eastern South Atlantic Ocean

Cystadenocarcinoma of the parotid: case report of a BRAF inhibitor treatment

Socio-economic impact of Rift Valley fever to pastoralists and agro pastoralists in Arusha, Manyara and Morogoro regions in Tanzania

Modelling survival data to account for model uncertainty: a single model or model averaging?

Oxygen doping of HTSC and resistive switching in HTSC-based heterostructures

Changes of bacterioplankton apparent species richness in two ornamental fish aquaria

Accessory renal arteries in a Caribbean population: a computed tomography based study

Analyses of Arabidopsis ecotypes reveal metabolic diversity to convert D-amino acids

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Bioequivalance and pharmacokinetic study of febuxostat in human plasma by using LC-MS/MS with liquid liquid extraction method

Year: 2013, Volume: 2, Issue: Suppl 1

Year: 2013, Volume: 2, Issue: 1

Year: 2012, Volume: 1

Innate immune response after adenoviral gene delivery into skin is mediated by AIM2, NALP3, DAI and mda5

Content Provider	PubMed Central
Author	Schulte, Matthias Sorkin, Michael Sammy, Al-benna Stupka, Jadwiga Hirsch, Tobias Daigeler, Adrien Kesting, Marco Rainer Steinau, Hans-ulrich Jacobsen, Frank Lars, Steinstraesser
Abstract	Methods for human skin gene therapy requires efficient and stable introduction of genes into skin cells. Transient cutaneous gene therapy is an attractive approach in the treatment of skin diseases. The ‘Achilles heel’ of adenoviral gene therapy is its immunogenicity and many aspects of adenovirus induced cutaneous immune reaction still remain unanswered, particularly the role of keratinocytes. Therefore, human keratinocytes were transfected with adenoviral DNA and cytokine expression was analyzed. Moreover, adenoviral transduction of full-skin was performed ex vivo and in vivo. We observed cytokine induction after cytoplasmatic internalization of adenoviral DNA into epidermal cells. Inhibition of AIM2, NALP3, DAI or mda5 downregulated the cytokine response. Transduction of immunocompetent mice led to a detectable transgene expression for 12 days. Re-application of the vector led to a decrease in intensity and duration of transgene expression limited to 4 days and an increased cytokine expression. In contrast, immunodeficient mice showed a reduced expression of cytokines after DNA internalization. AIM2, NALP3, DAI and mda5 are essential in the induction of an innate immune response towards adenoviral DNA. This immune reaction leads to a decrease in transduction efficiency of the vector after re-application and modulation of these receptor systems stabilizes transgene expression.
Related Links	http://dx.doi.org/10.1186/2193-1801-2-234
Starting Page	234
File Format	PDF
ISSN	21931801
e-ISSN	21931801
Journal	SpringerPlus
Volume Number	2
Language	English
Publisher	Springer International Publishing AG
Publisher Date	2013-01-01
Access Restriction	Open
Rights Holder	Springer International Publishing AG
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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