NDLI: RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.

Please wait, while we are loading the content...

Year: 2016, Volume: 36

Year: 2015, Volume: 36

Year: 2015, Volume: 35

Year: 2014, Volume: 35

Year: 2014, Volume: 34

Year: 2013, Volume: 33

Year: 2012, Volume: 32

Year: 2011, Volume: 31

Year: 2010, Volume: 30

Year: 2009, Volume: 29

Year: 2008, Volume: 28

Year: 2007, Volume: 27

Year: 2006, Volume: 26

Year: 2005, Volume: 25

Year: 2004, Volume: 24

Year: 2003, Volume: 23

Year: 2002, Volume: 23

Year: 2002, Volume: 22

Year: 2001, Volume: 21

Year: 2000, Volume: 20

Year: 1999, Volume: 19

Year: 1998, Volume: 18

Year: 1997, Volume: 17

Year: 1996, Volume: 16

Year: 1995, Volume: 15

Year: 1994, Volume: 14

Year: 1993, Volume: 13

Year: 1992, Volume: 12

Year: 1991, Volume: 11

Year: 1990, Volume: 10

Year: 1989, Volume: 9

Year: 1988, Volume: 8

Year: 1987, Volume: 7

Year: 1986, Volume: 6

Year: 1985, Volume: 5

Year: 1985, Volume: 5, Issue: 12

Year: 1985, Volume: 5, Issue: 11

Year: 1985, Volume: 5, Issue: 10

Year: 1985, Volume: 5, Issue: 9

Year: 1985, Volume: 5, Issue: 8

Activation of Ha-ras p21 by substitution, deletion, and insertion mutations.

Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies.

A putative origin of replication of plasmids derived from Epstein-Barr virus is composed of two cis-acting components.

Transformation of cultured Drosophila melanogaster cells with a dominant selectable marker.

A mutation allowing an mRNA secondary structure diminishes translation of Saccharomyces cerevisiae iso-1-cytochrome c.

Analysis of the mouse dhfr promoter region: existence of a divergently transcribed gene.

Analysis of an activatable promoter: sequences in the simian virus 40 late promoter required for T-antigen-mediated trans activation.

The level of expression of adenovirus type 2 transforming genes governs sensitivity to nonspecific immune cytolysis and other phenotypic properties of adenovirus 2-simian virus 40-transformed cell hybrids.

Molecular cloning and characterization of the STE7 and STE11 genes of Saccharomyces cerevisiae.

In vitro expression of human p53 cDNA clones and characterization of the cloned human p53 gene.

Synthesis of predominantly unspliced cytoplasmic RNAs by chimeric herpes simplex virus type 1 thymidine kinase-human beta-globin genes.

Suppressors of Saccharomyces cerevisiae his3 promoter mutations lacking the upstream element.

Transcriptional regulation of a gene encoding the small subunit of ribulose-1,5-bisphosphate carboxylase in soybean tissue is linked to the phytochrome response.

Neomycin resistance as a dominant selectable marker for selection and isolation of vaccinia virus recombinants.

Expression of a cell surface immobilization antigen during serotype transformation in Tetrahymena thermophila.

Control functions of adenovirus transformation region E1A gene products in rat and human cells.

Promoter domains required for expression of plasmid-borne copies of the herpes simplex virus thymidine kinase gene in virus-infected mouse fibroblasts and microinjected frog oocytes.

Delineation of transcriptional control signals within the Moloney murine sarcoma virus long terminal repeat.

Alternate utilization of two regulatory domains within the Moloney murine sarcoma virus long terminal repeat.

Deregulation of c-myc gene expression in human colon carcinoma is not accompanied by amplification or rearrangement of the gene.

Expression of human beta-globin genes in transgenic mice: effects of a flanking metallothionein-human growth hormone fusion gene.

Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonists.

Nuclear polyadenylate-binding protein.

Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4.

In vivo interactions of RNA polymerase II with genes of Drosophila melanogaster.

Regulation of simian virus 40 gene expression in Xenopus laevis oocytes.

Recombination hot spot in the human beta-globin gene cluster: meiotic recombination of human DNA fragments in Saccharomyces cerevisiae.

Reproducible and variable genomic rearrangements occur in the developing somatic nucleus of the ciliate Tetrahymena thermophila.

Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells.

Induction of acquired thermotolerance in Tetrahymena thermophila: effects of protein synthesis inhibitors.

Common regulatory elements control gene expression from polyoma early and late promoters in cells transformed by chimeric plasmids.

Topological requirements for homologous recombination among DNA molecules transfected into mammalian cells.

RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.

Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.

A genetic locus closely linked to a protease inhibitor gene complex controls the level of multiple RNA transcripts.

Sequence organization and developmental expression of an interspersed, repetitive element and associated single-copy DNA sequences in Dictyostelium discoideum.

Regulation of repressible acid phosphatase gene transcription in Saccharomyces cerevisiae.

Polyomavirus mutation that confers a cell-specific cis advantage for viral DNA replication.

Human glyceraldehyde-3-phosphate dehydrogenase: mRNA levels and enzyme activity in developing muscle.

Interferon-induced human protein with homology to protein Mx of influenza virus-resistant mice.

Homothallic switching of Saccharomyces cerevisiae mating type genes by using a donor containing a large internal deletion.

Year: 1985, Volume: 5, Issue: 7

Year: 1985, Volume: 5, Issue: 6

Year: 1985, Volume: 5, Issue: 5

Year: 1985, Volume: 5, Issue: 4

Year: 1985, Volume: 5, Issue: 3

Year: 1985, Volume: 5, Issue: 2

Year: 1985, Volume: 5, Issue: 1

Year: 1984, Volume: 4

Year: 1983, Volume: 3

Year: 1982, Volume: 2

Year: 1981, Volume: 1

RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.

Content Provider	PubMed Central
Author	Soares, M. B. Schon, E. Henderson, A. Karathanasis, S. K. Cate, R. Zeitlin, S. Chirgwin, J. Efstratiadis, A.
Abstract	Rats and mice have two, equally expressed, nonallelic genes encoding preproinsulin (genes I and II). Cytological hybridization with metaphase chromosomes indicated that both genes reside on rat chromosome I but are approximately 100,000 kilobases apart. In mice the two genes reside on two different chromosomes. DNA sequence comparisons of the gene-flanking regions in rats and mice indicated that the preproinsulin gene I has lost one of the two introns present in gene II, is flanked by a long (41-base) direct repeat, and has a remnant of a polydeoxyadenylate acid tract preceding the downstream direct repeat. These structural features indicated that gene I was generated by an RNA-mediated duplication-transposition event involving a transcript of gene II which was initiated upstream from the normal capping site. Sequence divergence analysis indicated that the pair of the original gene and its retroposed, but functional, counterpart (which appeared about 35 million years ago) is maintained by strong negative selection operating primarily on the segments encoding the chains of the mature hormone, whereas the segments encoding the parts of the polypeptide that are eliminated during processing and also the introns and the flanking regions are evolving neutrally.
Starting Page	2090
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	8
Volume Number	5
Language	English
Publisher Date	1985-08-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in