NDLI: Reduced prefrontal cortex activation using the Trail Making Test in schizophrenia

Content Provider	PubMed Central
Author	Fujiki, Ryo Morita, Kiichiro Sato, Mamoru Kamada, Yuji Kato, Yusuke Inoue, Masayuki Shoji, Yoshihisa Uchimura, Naohisa
Copyright Year	2013
Abstract	Schizophrenia has been associated with a deficit of the prefrontal cortex, which is involved in attention, executive processes, and working memory. The Trail Making Test (TMT) is administered in two parts, TMT-A and TMT-B. It is suggested that the difference in performance between part A and part B reflects executive processes. In this study, we compared the characteristics of hemodynamic changes during TMT tasks between 14 outpatients with schizophrenia and 14 age- and gender-matched healthy control subjects. Using multichannel near-infrared spectroscopy, we measured relative changes in oxygenated hemoglobin concentration, which reflects brain activity of the prefrontal cortex during this task. In both tasks, patients showed significantly smaller activation than controls and, in an assessment of executive functions, a subtraction of oxygenated hemoglobin (oxy-Hb) changes during TMT-A from those of TMT-B showed a decrease in cerebral lateralization and hypoactivity in patients. There was a significant negative correlation between oxy-Hb changes and the severity of psychiatric symptoms. These findings may characterize disease-related features, suggesting the usefulness of oxy-Hb change measurement during TMT tasks for assessing functional outcomes in schizophrenic patients.
Related Links	http://dx.doi.org/10.2147/ndt.s43137
Ending Page	685
Starting Page	675
File Format	PDF
ISSN	11766328
e-ISSN	11782021
Journal	Neuropsychiatric Disease and Treatment
Volume Number	9
Language	English
Publisher	Dove Medical Press
Publisher Date	2013-05-01
Access Restriction	Open
Rights Holder	Dove Medical Press
Subject Keyword	Biological Psychiatry Psychiatry and Mental health Research in Higher Education
Content Type	Text
Resource Type	Article

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