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| Content Provider | PubMed Central |
|---|---|
| Author | Ilaria, Roato |
| Copyright Year | 2013 |
| Abstract | Bone metastases are a dismal consequence for different types of solid tumors, such as breast, prostate, lung, and kidney cancer. The mechanisms regulating the interactions among bone, immune system, and tumor cells have been deeply investigated, and many studies are ongoing to define the specific role of the different cells in the bone metastatic process. The affinity of some tumors to growth in bone results from the special microenvironment provided by bone. Moreover, immune system and bone have a bidirectional relationship: bone cells express surface molecules ruling the expansion of hemopoietic stem cells from which all cells of the mammalian immune system derive, and various immunoregulatory cytokines influence the fate of bone cells. The last findings allow to extend the concept of vicious cycle and add T cells as mediators of the tumor growth in bone. |
| Related Links | http://dx.doi.org/10.1155/2013/315024 |
| Starting Page | 315024 |
| File Format | |
| ISSN | 17402530 |
| e-ISSN | 17402530 |
| Journal | Clinical and Developmental Immunology |
| Volume Number | 2013 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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