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| Content Provider | PubMed Central |
|---|---|
| Author | Jung, Dae Young Ko, Hwi Jin Lichtman, Eben I. Lee, Eunjung Lawton, Elizabeth Ong, Helena Yu, Kristine Azuma, Yoshihiro Friedline, Randall H. Lee, Ki Won Kim, Jason K. |
| Copyright Year | 2013 |
| Abstract | Obesity is a major cause of insulin resistance, and weight loss is shown to improve glucose homeostasis. But the underlying mechanism and the role of inflammation remain unclear. Male C57BL/6 mice were fed a high-fat diet (HFD) for 12 wk. After HFD, weight loss was induced by changing to a low-fat diet (LFD) or exercise with continuous HFD. The weight loss effects on energy balance and insulin sensitivity were determined using metabolic cages and hyperinsulinemic euglycemic clamps in awake mice. Diet and exercise intervention for 3 wk caused a modest weight loss and improved glucose homeostasis. Weight loss dramatically reduced local inflammation in skeletal muscle, liver, and heart but not in adipose tissue. Exercise-mediated weight loss increased muscle glucose metabolism without affecting Akt phosphorylation or lipid levels. LFD-mediated weight loss reduced lipid levels and improved insulin sensitivity selectively in liver. Both weight loss interventions improved cardiac glucose metabolism. These results demonstrate that a short-term weight loss with exercise or diet intervention attenuates obesity-induced local inflammation and selectively improves insulin sensitivity in skeletal muscle and liver. Our findings suggest that local factors, not adipose tissue inflammation, are involved in the beneficial effects of weight loss on glucose homeostasis. |
| Related Links | http://dx.doi.org/10.1152/ajpendo.00462.2012 |
| Starting Page | 964 |
| File Format | |
| ISSN | 01931849 |
| e-ISSN | 15221555 |
| Journal | American Journal of Physiology - Endocrinology and Metabolism |
| Issue Number | 9 |
| Volume Number | 304 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2013-05-01 |
| Access Restriction | Open |
| Rights Holder | American Physiological Society |
| Subject Keyword | Physiology (medical) Physiology Endocrinology, Diabetes and Metabolism Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Endocrinology, Diabetes and Metabolism Physiology (medical) |
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