NDLI: Ovine Fetal Immune Response to Cache Valley Virus Infection

Content Provider	PubMed Central
Author	Hoffmann, Aline Rodrigues Dorniak, Piotr Filant, Justyna Dunlap, Kathrin A. Bazer, Fuller W. Andres, De La Concha-bermejillo Welsh, Christabel Jane Varner, Patricia Edwards, John Francis
Copyright Year	2013
Abstract	Cache Valley virus (CVV)-induced malformations have been previously reproduced in ovine fetuses. To evaluate the development of the antiviral response by the early, infected fetus, before the development of immunocompetency, ovine fetuses at 35 days of gestation were inoculated in utero with CVV and euthanized at 7, 10, 14, 21, and 28 days postinfection. The antiviral immune response in immature fetuses infected with CVV was evaluated. Gene expression associated with an innate, immune response was quantified by real-time quantitative PCR. The upregulated genes in infected fetuses included ISG15, Mx1, Mx2, IL-1, IL-6, TNF-α, TLR-7, and TLR-8. The amount of Mx1 protein, an interferon-stimulated GTPase capable of restricting growth of bunyaviruses, was elevated in the allantoic and amniotic fluid in infected fetuses. ISG15 protein expression was significantly increased in target tissues of infected animals. B lymphocytes and immunoglobulin-positive cells were detected in lymphoid tissues and in the meninges of infected animals. These results demonstrated that the infected ovine fetus is able to initiate an innate and adaptive immune response much earlier than previously known, which presumably contributes to viral clearance in infected animals.
Related Links	http://dx.doi.org/10.1128/JVI.01821-12
Ending Page	5592
Page Count	7
Starting Page	5586
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	10
Volume Number	87
Language	English
Publisher	American Society for Microbiology
Publisher Date	2013-05-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Identification of the Target Cells and Sequence of Infection during Experimental Infection of Ovine Fetuses with Cache Valley Virus

Transcriptional Profiling of the Immune Response to Marburg Virus Infection

Simulation and Prediction of the Adaptive Immune Response to Influenza A Virus Infection▿

Role of the humoral immune response in resistance to Theiler's virus infection.

Impaired Immune Response to Vaccination against Infection with Human Respiratory Syncytial Virus at Advanced Age

Risk of Immunodeficiency Virus Infection May Increase with Vaccine-Induced Immune Response

CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) In Vitro and Immune Response to EMCV Infection In Vivo

Endothelial Cells Elicit Immune-Enhancing Responses to Dengue Virus Infection

Immune Response to Individual Maedi-Visna Virus gag Antigens

Ovine Fetal Immune Response to Cache Valley Virus Infection

Similar Documents

Identification of the Target Cells and Sequence of Infection during Experimental Infection of Ovine Fetuses with Cache Valley Virus

Transcriptional Profiling of the Immune Response to Marburg Virus Infection

Simulation and Prediction of the Adaptive Immune Response to Influenza A Virus Infection▿

Role of the humoral immune response in resistance to Theiler's virus infection.

Impaired Immune Response to Vaccination against Infection with Human Respiratory Syncytial Virus at Advanced Age

Risk of Immunodeficiency Virus Infection May Increase with Vaccine-Induced Immune Response

CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) In Vitro and Immune Response to EMCV Infection In Vivo

Endothelial Cells Elicit Immune-Enhancing Responses to Dengue Virus Infection

Immune Response to Individual Maedi-Visna Virus gag Antigens

Ovine Fetal Immune Response to Cache Valley Virus Infection