NDLI: CD4+ T Cells Develop Antiretroviral Cytotoxic Activity in the Absence of Regulatory T Cells and CD8+ T Cells

Content Provider	PubMed Central
Author	Manzke, Nora Akhmetzyanova, Ilseyar Hasenkrug, Kim J. Trilling, Mirko Zelinskyy, Gennadiy Dittmer, Ulf
Copyright Year	2013
Abstract	Conventional CD4+ T cells play an important role in viral immunity. In most virus infections, they provide essential help for antiviral B and T cell responses. In chronic infections, including HIV infection, an expansion of regulatory T cells (Tregs) has been demonstrated, which can suppress virus-specific CD4+ T cell responses in vitro. However, the suppressive activity of Tregs on effector CD4+ T cells in retroviral infection is less well documented in vivo. We took advantage of a transgenic mouse in which Tregs can be selectively depleted to determine the influence of such cells on retrovirus-specific CD4+ T cell responses during an ongoing infection. Mice were infected with Friend retrovirus (FV), and Tregs were depleted during the acute phase of the infection. In nondepleted mice, activated CD4+ T cells produced Th1-type cytokines but did not exhibit any antiviral cytotoxicity as determined in a major histocompatibility complex (MHC) class II-restricted in vivo cytotoxic T lymphocyte (CTL) assay. Depletion of Tregs significantly increased the numbers of virus-specific CD4+ T cells and improved their cytokine production, whereas it induced only very little CD4+ T cell cytotoxicity. However, after dual depletion of Tregs and CD8+ T cells, conventional CD4+ T cells developed significant cytotoxic activity against FV epitope-labeled target cells in vivo and contributed to the control of virus replication. Thus, both Tregs and CD8+ T cells influence the cytotoxic activity of conventional CD4+ T cells during an acute retroviral infection.
Related Links	http://dx.doi.org/10.1128/JVI.00432-13
Ending Page	6313
Page Count	8
Starting Page	6306
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	11
Volume Number	87
Language	English
Publisher	American Society for Microbiology
Publisher Date	2013-06-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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