NDLI: Integrated Bi-Layered Scaffold for Osteochondral Tissue Engineering

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Integrated Bi-Layered Scaffold for Osteochondral Tissue Engineering

Content Provider	PubMed Central
Author	Galperin, Anna Oldinski, Rachael A. Florczyk, Stephen J. Bryers, James D. Zhang, Miqin Ratner, Buddy D.
Copyright Year	2012
Abstract	Osteochondral tissue engineering poses the challenge of combining both cartilage and bone tissue engineering fundamentals. In this study, a sphere-templating technique was applied to fabricate an integrated bi-layered scaffold based on degradable poly(hydroxyethyl methacrylate) hydrogel. One layer of the integrated scaffold was designed with a single defined, monodispersed pore size of 38 μm and pore surfaces coated with hydroxyapatite particles to promote regrowth of subchondral bone while the second layer had 200 μm pores with surfaces decorated with hyaluronan for articular cartilage regeneration. Mechanical properties of the construct as well as cyto-compatibility of the scaffold and its degradation products were elucidated. To examine the potential of the biphasic scaffold for regeneration of osteochondral tissue the designated cartilage and bone layers of the integrated bi-layered scaffold were seeded with chondrocytes differentiated from human mesenchymal stem cells and primary human mesenchymal stem cells, respectively. Both types of cells were co-cultured within the scaffold in standard medium without soluble growth/differentiation factors over four weeks. The ability of the integrated bi-layered scaffold to support simultaneous matrix deposition and adequate cell growth of two distinct cell lineages in each layer during four weeks of co-culture in vitro in the absence of soluble growth factors was demonstrated.
Related Links	http://dx.doi.org/10.1002/adhm.201200345
Ending Page	883
Page Count	12
Starting Page	872
File Format	PDF
ISSN	21922640
e-ISSN	21922659
Journal	Advanced healthcare materials
Issue Number	6
Volume Number	2
Language	English
Publisher Date	2013-06-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biomedical Engineering Pharmaceutical Science

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