NDLI: Li Fraumeni syndrome, cancer and senescence: a new hypothesis

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TLR9 signaling repressed tumor suppressor miR-7 expression through up-regulation of HuR in human lung cancer cells

MiR-214 regulate gastric cancer cell proliferation, migration and invasion by targeting PTEN

Notch1 signaling is involved in regulating Foxp3 expression in T-ALL

Up-regulation of miR-224 promotes cancer cell proliferation and invasion and predicts relapse of colorectal cancer

A specific miRNA signature promotes radioresistance of human cervical cancer cells

Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line

Release and uptake of volatile organic compounds by human hepatocellular carcinoma cells (HepG2) in vitro

Expression pattern of the apoptosis-stimulating protein of p53 family in p53+ human breast cancer cell lines

Nip the HPV encoded evil in the cancer bud: HPV reshapes TRAILs and signaling landscapes

Correction: Granulocyte-macrophage stimulating factor (GM-CSF) increases circulating dendritic cells but does not abrogate suppression of adaptive cellular immunity in patients with metastatic colorectal cancer receiving chemotherapy

The expression and clinical significance of HERC4 in breast cancer

CpG oligodeoxynucleotides enhance chemosensitivity of 5-fluorouracil in HepG2 human hepatoma cells via downregulation of the antiapoptotic factors survivin and livin

MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis

The role of peptide and DNA vaccines in myeloid leukemia immunotherapy

Chemosensetizing and cardioprotective effects of resveratrol in doxorubicin- treated animals

Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines

Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway

Role of relaxin-2 in human primary osteosarcoma

Selective growth inhibition of human malignant melanoma cells by syringic acid-derived proteasome inhibitors

Genistein promotes cell death of ethanol-stressed HeLa cells through the continuation of apoptosis or secondary necrosis

Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture

Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells

Mifepristone improves chemo-radiation response in glioblastoma xenografts

The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells

SU6668 suppresses proliferation of triple negative breast cancer cells through down-regulating MTDH expression

Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells

Signaling pathway switch in breast cancer

Oral squamous cell carcinoma in relation to field precancerisation: pathobiology

Cancer: a “stem-cell” disease?

Overexpression of p65 attenuates celecoxib-induced cell death in MDA-MB-231 human breast cancer cell line

The in vitro influences of epidermal growth factor and heregulin-β1 on the efficacy of trastuzumab used in Her-2 positive breast adenocarcinoma

Downregulation of the H-2Kd gene by siRNA affects the cytotoxicity of murine LAK cells

Depleting NFAT1 expression inhibits the ability of invasion and migration of human lung cancer cells

Curcumin induces apoptosis in gallbladder carcinoma cell line GBC-SD cells

Disrupting the CXCL12/CXCR4 axis disturbs the characteristics of glioblastoma stem-like cells of rat RG2 glioblastoma

BAD overexpression inhibits cell growth and induces apoptosis via mitochondrial-dependent pathway in non-small cell lung cancer

3,4-dihydroxyphenyl acetic acid and (+)-epoxydon isolated from marine algae-derived microorganisms induce down regulation of epidermal growth factor activated mitogenic signaling cascade in Hela cells

Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations

Establishment and characterization of clear cell renal cell carcinoma cell lines with different metastatic potential from Chinese patients

Combining the negative lymph nodes count with the ratio of positive and removed lymph nodes can better predict the postoperative survival in cervical cancer patients

Functional features of cancer stem cells in melanoma cell lines

Expression of MACC1 and c-Met in human gastric cancer and its clinical significance

Celastrol induces apoptosis of gastric cancer cells by miR-146a inhibition of NF-κB activity

Functional disruption of macrophage migration inhibitory factor (MIF) suppresses proliferation of human H460 lung cancer cells by caspase-dependent apoptosis

Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing’s sarcoma cells for apoptosis

Correction: MiRNA-26b inhibits proliferation by targeting PTGS2 in breast cancer

Target delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model

MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6

The effects of a histone deacetylase inhibitor on biological behavior of diffuse large B-cell lymphoma cell lines and insights into the underlying mechanisms

The flavokawains: uprising medicinal chalcones

Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer

The association between polymorphisms in the MDR1 gene and risk of cancer: a systematic review and pooled analysis of 52 case–control studies

Retraction: The stem cell factor antibody enhances the chemotherapeutic effect of adriamycin on chemoresistant breast cancer cells

Li Fraumeni syndrome, cancer and senescence: a new hypothesis

Association of integrin beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small cell lung cancer

Single nucleotide polymorphisms of CD20 gene and their relationship with clinical efficacy of R-CHOP in patients with diffuse large B cell lymphoma

X-ray irradiation promotes apoptosis of hippocampal neurons through up-regulation of Cdk5 and p25

Blockade of PI3K/AKT pathway enhances sensitivity of Raji cells to chemotherapy through down-regulation of HSP70

PI3-kinase inhibition synergistically promoted the anti-tumor effect of lupeol in hepatocellular carcinoma

Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation

Influence on the behavior of lung cancer H1299 cells by silencing SLC35F2 expression

DNMT3A mutations and clinical features in Chinese patients with acute myeloid leukemia

Changes in the MALT1-A20-NF-κB expression pattern may be related to T cell dysfunction in AML

Expression of ALDH1 in breast invasive ductal carcinoma: an independent predictor of early tumor relapse

Hydrogen peroxide (H2O2) induces leukemic but not normal hematopoietic cell death in a dose-dependent manner

Wilms’ tumour suppressor gene 1 (WT1) is involved in the carcinogenesis of Lung cancer through interaction with PI3K/Akt pathway

Independent of ErbB1 gene copy number, EGF stimulates migration but is not associated with cell proliferation in non-small cell lung cancer

Thanks to Cancer Cell International reviewers (2012)

Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells

Trimethoxy-benzaldehyde levofloxacin hydrazone inducing the growth arrest and apoptosis of human hepatocarcinoma cells

Mirk/Dyrk1B mediates G0/G1 to S phase cell cycle progression and cell survival involving MAPK/ERK signaling in human cancer cells

Beclin1 inhibition promotes autophagy and decreases gemcitabine–induced apoptosis in Miapaca2 pancreatic cancer cells

Response to microtubule-interacting agents in primary epithelial ovarian cancer cells

Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells

Molecular crosstalk between apoptosis and autophagy induced by a novel 2-methoxyestradiol analogue in cervical adenocarcinoma cells

Expression patterns of Phf5a/PHF5A and Gja1/GJA1 in rat and human endometrial cancer

Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal

miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor

Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway

Tumor cell response to bevacizumab single agent therapy in vitro

Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani

CpG island hypermethylation-associated silencing of microRNAs promotes human endometrial cancer

Prognosis of the intrahepatic cholangiocarcinoma after resection: hepatitis B virus infection and adjuvant chemotherapy are favorable prognosis factors

HOXB1 restored expression promotes apoptosis and differentiation in the HL60 leukemic cell line

Antiproliferative activity and apoptosis-inducing mechanism of constituents from Toona sinensis on human cancer cells

MiRNA-26b inhibits proliferation by targeting PTGS2 in breast cancer

Candidate microRNA biomarkers in human epithelial ovarian cancer: systematic review profiling studies and experimental validation

Spindle and kinetochore associated complex subunit 1 regulates the proliferation of oral adenosquamous carcinoma CAL-27 cells in vitro

FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia

MiRNA-497 regulates cell growth and invasion by targeting cyclin E1 in breast cancer

High expression of prolactin receptor is associated with cell survival in cervical cancer cells

Silencing SATB1 with siRNA inhibits the proliferation and invasion of small cell lung cancer cells

Caspase-2 is involved in cell death induction by taxanes in breast cancer cells

Cell-cycle synchronization reverses Taxol resistance of human ovarian cancer cell lines

CD44 targets Wnt/β-catenin pathway to mediate the proliferation of K562 cells

Determination of the apoptotic index in osteosarcoma tissue and its relationship with patients prognosis

Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay

Correction: Functional disruption of macrophage migration inhibitory factor (MIF) suppresses proliferation of human h460 lung cancer cells by caspase-dependent apoptosis

MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma

Validation of suitable endogenous control genes for quantitative PCR analysis of microRNA gene expression in a rat model of endometrial cancer

The mitochondrial C16069T polymorphism, not mitochondrial D310 (D-loop) mononucleotide sequence variations, is associated with bladder cancer

Effect of DNA methylation inhibitor on RASSF1A genes expression in non-small cell lung cancer cell line A549 and A549DDP

EGCG induces human mesothelioma cell death by inducing reactive oxygen species and autophagy

TWIST1, A novel androgen-regulated gene, is a target for NKX3-1 in prostate cancer cells

Promoter methylation status of the tumor suppressor gene SOX11 is associated with cell growth and invasion in nasopharyngeal carcinoma

A characterization of four B16 murine melanoma cell sublines molecular fingerprint and proliferation behavior

Anti-cancer effects of ginsenoside compound k on pediatric acute myeloid leukemia cells

Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice

Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo

Positive association between Interleukin-8 -251A > T polymorphism and susceptibility to gastric carcinogenesis: a meta-analysis

Inhibition of tumor promoting signals by activation of SSTR2 and opioid receptors in human breast cancer cells

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Li Fraumeni syndrome, cancer and senescence: a new hypothesis

Content Provider	PubMed Central
Author	Pan, Tziarka
Copyright Year	2013
Abstract	Li Fraumeni Syndrome (LFS) is a rare autosomal dominant hereditary cancer syndrome characterized by germline mutations in the TP53 tumour suppressor gene. Sufferers are prone to early onset cancers, particularly sarcomas, adrenocortical carcinoma and breast cancer. Cells from LFS sufferers are known to exhibit telomere dysfunction, genomic instability and spontaneous immortalisation. It is hypothesized that these facets of the LFS host are evidence that the host environment is “primed” for carcinogenesis over and above the lack of p53 tumour suppressor function. Further, it is hypothesized that the host presents an ideal environment for "two compartment tumour metabolism" to take place. Evidence from recent studies supports this new view of LFS and suggests that disrupting certain features of the host environment may markedly reduce the incidence of cancer in LFS sufferers.
Related Links	http://dx.doi.org/10.1186/1475-2867-13-35
Ending Page	35
Page Count	1
Starting Page	35
File Format	PDF
ISSN	14752867
e-ISSN	14752867
Journal	Cancer Cell International
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2013-04-15
Access Restriction	Open
Rights Holder	BioMed Central
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Oncology

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