NDLI: Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes.

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Unit-length line-1 transcripts in human teratocarcinoma cells.

Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes.

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The Saccharomyces cerevisiae genome contains functional and nonfunctional copies of transposon Ty1.

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Characterization of antigen receptor response elements within the interleukin-2 enhancer.

Expression of the human beta-globin gene after retroviral transfer into murine erythroleukemia cells and human BFU-E cells.

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Substitution of Ser-17 of pp60c-src: biological and biochemical characterization in chicken embryo fibroblasts.

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.

Alternative splicing of RNAs transcribed from the chicken c-mil gene.

Mutations in poly(A) site downstream elements affect in vitro cleavage activity.

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Rejection of B16 melanoma induced by expression of a transfected major histocompatibility complex class I gene.

The Cell-Specific Elastase I Enhancer Comprises Two Domains

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Enhancer and promoter elements directing activation and glucocorticoid repression of the alpha 1-fetoprotein gene in hepatocytes.

Content Provider	PubMed Central
Author	Guertin, M. Larue, H. Bernier, D. Wrange, O. Chevrette, M. Gingras, M. C. Bélanger, L.
Abstract	Mutations were introduced in 7 kilobases of 5'-flanking rat alpha 1-fetoprotein (AFP) genomic DNA, linked to the chloramphenicol acetyltransferase gene. AFP promoter activity and its repression by a glucocorticoid hormone were assessed by stable and transient expression assays. Stable transfection assays were more sensitive and accurate than transient expression assays in a Morris 7777 rat hepatoma recipient (Hepa7.6), selected for its strong AFP repression by dexamethasone. The segment of DNA encompassing a hepatocyte-constitutive chromatin DNase I-hypersensitive site at -3.7 kilobases and a liver developmental stage-specific site at -2.5 kilobases contains interacting enhancer elements sufficient for high AFP promoter activity in Hepa7.6 or HepG2 cells. Deletions and point mutations define an upstream promoter domain of AFP gene activation, operating with at least three distinct promoter-activating elements, PEI at -65 base pairs, PEII at -120 base pairs, and DE at -160 base pairs. PEI and PEII share homologies with albumin promoter sequences, PEII is a near-consensus nuclear factor I recognition sequence, and DE overlaps a glucocorticoid receptor recognition sequence. An element conferring glucocorticoid repression of AFP gene activity is located in the upstream AFP promoter domain. Receptor-binding assays indicate that this element is the glucocorticoid receptor recognition sequence which overlaps with promoter-activating element DE.
Starting Page	1398
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	4
Volume Number	8
Language	English
Publisher Date	1988-04-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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