NDLI: Neural progenitors organize in small-world networks to promote cell proliferation

Content Provider	PubMed Central
Author	Seth, Malmersjö Rebellato, Paola Erik, Smedler Planert, Henrike Kanatani, Shigeaki Liste, Isabel Nanou, Evanthia Sunner, Hampus Abdelhady, Shaimaa Zhang, Songbai Michael, Andäng El, Manira Abdeljabbar Silberberg, Gilad Arenas, Ernest Per, Uhlén
Abstract	Synchronized activity among groups of interconnected cells is essential for diverse functions in the brain. Most studies on neuronal networks have been performed in the mature brain when chemical synapses have been established. However, less is known about networking during embryonic development. We have studied neural progenitors and found that they form gap junction-mediated small-world networks, which, via electrical depolarization, drive spontaneous calcium activity to stimulate cell proliferation. Our data underscore the critical role of intricate cell signaling during embryonic development and show that complex networks of immature cells exist in the brain before birth.
Related Links	http://dx.doi.org/10.1073/pnas.1220179110
Starting Page	1524
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	16
Volume Number	110
Language	English
Publisher	National Academy of Sciences
Publisher Date	2013-04-16
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Neural progenitors organize in small-world networks to promote cell proliferation