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| Content Provider | PubMed Central |
|---|---|
| Author | Tian, Y. S. Rong, T. Z. Hong, Y. L. Min, L. Jian, P. G. |
| Copyright Year | 2013 |
| Abstract | It has been demonstrated that ischemic postconditioning (IPO) is capable of attenuating ischemia/reperfusion (I/R) injury in the heart. However, the novel role of pharmacological postconditioning in the liver remains unclear. In this study, the hypothesis that diazoxide postconditioning reduces I/R-induced injury in rat liver was tested. Rats were assigned randomly to the sham-operated control, I/R (occlusion of the porta hepatis for 60 min, followed by a persistent reperfusion for 120 min), diazoxide ischemic postconditioning (DIPO; occlusion of the porta hepatis for 60 min, then treatment with diazoxide for 10 min reperfusion, followed by a persistent reperfusion for 110 min) or 5-hydroxydecanoate (5-HD)+DIPO (occlusion of the porta hepatis for 60 min, then treatment with diazoxide and 5-HD for 10 min reperfusion, followed by a persistent reperfusion for 110 min) groups. The alanine aminotransferase (ALT) and aspartate transaminase (AST) levels were assayed. The expression levels of protein kinase c-ε (pkc-ε), cytochrome c (cyt-c), caspase-3 and bcl-2 protein were determined by western blotting. The serum levels of ALT and AST and expression levels of cyt-c and caspase-3 were significantly lower in the DIPO group (P<0.05). However, the protein expression levels of pkc-ε and bcl-2 were markedly increased in the DIPO group (P<0.05). 5-HD abrogated the protective effects of DIPO. The data of the present study provide the first evidence that DIPO protects the liver from I/R injury by opening the mitochondrial KATP channels, activating and upregulating pkc-ε and inhibiting the activation of the apoptotic pathway by decreasing the release of cyt-c and the expression of caspase-3 and increasing bcl-2 expression. |
| Related Links | http://dx.doi.org/10.3892/etm.2013.941 |
| Ending Page | 1173 |
| Page Count | 5 |
| Starting Page | 1169 |
| File Format | |
| ISSN | 17920981 |
| e-ISSN | 17921015 |
| Journal | Experimental and Therapeutic Medicine |
| Issue Number | 4 |
| Volume Number | 5 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2013-01-01 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Immunology and Microbiology (miscellaneous) Cancer Research Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research 2400/2401 |
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