NDLI: Posttranscriptional regulation of cellular gene expression by the c-myc oncogene.

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Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia.

Mechanism of activation of the human trk oncogene.

Molecular and biochemical characterization of the human trk proto-oncogene.

Adjacent upstream activation sequence elements synergistically regulate transcription of ADH2 in Saccharomyces cerevisiae.

Specific binding of estrogen receptor to the estrogen response element.

Class II box consensus sequences in the HLA-DR alpha gene: transcriptional function and interaction with nuclear proteins.

Involvement of proliferating cell nuclear antigen (cyclin) in DNA replication in living cells.

Somatic mutation and transcriptional deregulation of myc in endemic Burkitt's lymphoma disease: heptamer-nonamer recognition mistakes?

Peroxisome targeting signal of rat liver acyl-coenzyme A oxidase resides at the carboxy terminus.

Tissue-specific expression and developmental regulation of the human fgr proto-oncogene.

Construction and properties of replication-competent murine retroviral vectors encoding methotrexate resistance.

Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.

Steady-state physiological variations across a graded series of Na,K-ATPase-amplified cells.

Posttranscriptional regulation of cellular gene expression by the c-myc oncogene.

Nerve growth factor regulates gene expression by several distinct mechanisms.

The general control activator protein GCN4 is essential for a basal level of ARO3 gene expression in Saccharomyces cerevisiae.

The yeast G-protein homolog is involved in the mating pheromone signal transduction system.

DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage.

Replication of DNA minicircles in kinetoplasts isolated from Crithidia fasciculata: structure of nascent minicircles.

Spontaneous germ line virus infection and retroviral insertional mutagenesis in eighteen transgenic Srev lines of mice.

Isolation and characterization of related cDNA clones encoding skeletal muscle beta-tropomyosin and a low-molecular-weight nonmuscle tropomyosin isoform.

Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitro.

Mechanism of autocrine stimulation in hematopoietic cells producing interleukin-3 after retrovirus-mediated gene transfer.

Glycosylation and secretion of human tissue plasminogen activator in recombinant baculovirus-infected insect cells.

Ribosomal protein L7a is encoded by a gene (Surf-3) within the tightly clustered mouse surfeit locus.

Synthesis of p36 and p35 is increased when U-937 cells differentiate in culture but expression is not inducible by glucocorticoids.

Transcriptional promiscuity of the human alpha-globin gene.

Role of arachidonic acid metabolism in transcriptional induction of tumor necrosis factor gene expression by phorbol ester.

A block in mammalian splicing occurring after formation of large complexes containing U1, U2, U4, U5, and U6 small nuclear ribonucleoproteins.

UbiA, the major polyubiquitin locus in Caenorhabditis elegans, has unusual structural features and is constitutively expressed.

Abelson murine leukemia virus induces platelet-derived growth factor-independent fibroblast growth: correlation with kinase activity and dissociation from full morphologic transformation.

c-myc RNA degradation in growing and differentiating cells: possible alternate pathways.

Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene.

Anatomy of a new B-cell-specific enhancer.

New B-lymphocyte-specific enhancer-binding protein.

An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene.

Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown.

A synthetic intron in a naturally intronless yeast pre-tRNA is spliced efficiently in vivo.

Perturbation of chromatin architecture on ecdysterone induction of Drosophila melanogaster small heat shock protein genes.

Electron microscopy reveals that transcription factor TFIIIA bends 5S DNA.

Stability of transcription complexes on class II genes.

An overhanging 3' terminus is a conserved feature of telomeres.

Structural determinant of the species-specific transcription of the mouse rRNA gene promoter.

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Posttranscriptional regulation of cellular gene expression by the c-myc oncogene.

Content Provider	PubMed Central
Author	Prendergast, G. C. Cole, M. D.
Abstract	The c-myc oncogene has been implicated in the development of many different cancers, yet the mechanism by which the c-myc protein alters cellular growth control has proven elusive. We used a cDNA hybridization difference assay to isolate two genes, mr1 and mr2, that were constitutively expressed (i.e., deregulated) in rodent fibroblast cell lines immortalized by transfection of a viral promoter-linked c-myc gene. Both cDNAs were serum inducible in quiescent G0 fibroblasts, suggesting that they are functionally related to cellular proliferative processes. Although there were significant differences in cytoplasmic mRNA levels between myc-immortalized and control cells, the rates of transcription and mRNA turnover of both genes were similar, suggesting that c-myc regulates mr1 and mr2 expression by some nuclear posttranscriptional mechanism. mr1 was also rapidly (within 2 h) and specifically induced by dexamethasone in BALB/c cell lines expressing a mouse mammary tumor virus long terminal repeat-driven myc gene, under conditions where other growth factor-inducible genes were unaffected. A frameshift mutation in the mouse mammary tumor virus myc gene destroyed the dexamethasone stimulation of mr1, indicating that c-myc protein is required for the effect. As in the myc-immortalized cells, the induction of mr1 by c-myc occurred without detectable changes in mr1 transcription or cytoplasmic mRNA stability, implicating regulation, either direct or indirect, through a nuclear posttranscriptional mechanism. These results provide evidence that c-myc can rapidly modulate cellular gene expression and suggest that c-myc may function in gene regulation at the level of RNA export, splicing, or nuclear RNA turnover.
Starting Page	124
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	1
Volume Number	9
Language	English
Publisher Date	1989-01-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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