NDLI: Drosophila Social Clustering is Disrupted by Anesthetics and in narrow abdomen Ion Channel Mutants

Please wait, while we are loading the content...

Drosophila Social Clustering is Disrupted by Anesthetics and in narrow abdomen Ion Channel Mutants

Content Provider	PubMed Central
Author	Burg, Elyssa D. Langan, Sara T. Nash, Howard A.
Abstract	Members of many species tend to congregate, a behavioral strategy known as local enhancement. Selective advantages of local enhancement range from efficient use of resources to defense from predators. While previous studies have examined many types of social behavior in fruit flies, few have specifically investigated local enhancement. Resource-independent local enhancement has recently been described in the fruit fly using a measure called social space index, although the neural mechanisms remain unknown. Here we analyze resource-independent local enhancement of Drosophila under conditions that allow us to elucidate its neural mechanisms. We have investigated the effects of general volatile anesthetics, compounds that compromise higher order functioning of the type typically required for responding to social cues. We exposed Canton-S flies to non-immobilizing concentrations of halothane and found that flies had a significantly decreased social space index compared to flies tested in air. Narrow abdomen (na) mutants, which display altered responses to anesthetics in numerous behavioral assays, also have a significantly reduced social space index, an effect that was fully reversed by restoring expression of na by driving a UAS-NA rescue construct with NA-GAL4. We found that na expression in cholinergic neurons fully rescued the behavioral defect, whereas expression of na in glutamatergic neurons did so only partially. Our results also suggest a role for na expression in the mushroom bodies, since suppressing na expression in the mushroom bodies of NA-GAL4 rescue flies diminishes social space index. Our data indicate that resource-independent local enhancement, a simple behavioral strategy, requires complex neural processing.
Related Links	http://dx.doi.org/10.1111/gbb.12025
Ending Page	347
Page Count	10
Starting Page	338
File Format	PDF
ISSN	16011848
e-ISSN	1601183X
Journal	Genes, brain, and behavior
Issue Number	3
Volume Number	12
Language	English
Publisher Date	2013-04-01
Access Restriction	Open
Subject Keyword	Genetics Behavioral Neuroscience Neurology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neurology Genetics Behavioral Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Drosophila social clustering is disrupted by anesthetics and in narrow abdomen ion channel mutants.

The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity

The Drosophila TRPA channel, Painless, regulates sexual receptivity in virgin females

Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning

UNC79 and UNC80, Putative Auxiliary Subunits of the NARROW ABDOMEN Ion Channel, Are Indispensable for Robust Circadian Locomotor Rhythms in Drosophila

A simple assay to study social behavior in Drosophila: measurement of social space within a group

New Synaptic Bouton Formation Is Disrupted by Misregulation of Microtubule Stability in aPKC Mutants

Unidirectional startle responses and disrupted left-right coordination of motor behaviors in robo3 mutant zebrafish

The Relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects

Drosophila Social Clustering is Disrupted by Anesthetics and in narrow abdomen Ion Channel Mutants

Similar Documents

Drosophila social clustering is disrupted by anesthetics and in narrow abdomen ion channel mutants.

The Narrow Abdomen Ion Channel Complex Is Highly Stable and Persists from Development into Adult Stages to Promote Behavioral Rhythmicity

The Drosophila TRPA channel, Painless, regulates sexual receptivity in virgin females

Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning

UNC79 and UNC80, Putative Auxiliary Subunits of the NARROW ABDOMEN Ion Channel, Are Indispensable for Robust Circadian Locomotor Rhythms in Drosophila

A simple assay to study social behavior in Drosophila: measurement of social space within a group

New Synaptic Bouton Formation Is Disrupted by Misregulation of Microtubule Stability in aPKC Mutants

Unidirectional startle responses and disrupted left-right coordination of motor behaviors in robo3 mutant zebrafish

The Relationship between naloxone-induced cortisol and mu opioid receptor availability in mesolimbic structures is disrupted in alcohol dependent subjects

Drosophila Social Clustering is Disrupted by Anesthetics and in narrow abdomen Ion Channel Mutants