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| Content Provider | PubMed Central |
|---|---|
| Author | Schumacher, Thomas Claus, Ruehland Schultheiss, Christine Brinkman, Marc Roedel, Franz Reiser, Christian O. A. Hess, Juergen Reichel, Christoph |
| Copyright Year | 2007 |
| Abstract | Success in cancer immunotherapy depends on the identification and efficient targeting of specific tumor-associated antigens. Two pivotal strategies to prime patients’ immune system against malignant cells are tumor-specific adoptive T-cell therapy and tumor-specific vaccination. Here, we will focus on immunotherapeutic vaccination and discuss the advantages and disadvantages of different strategies to deliver tumor-specific T-cell epitopes. A particular focus will be put on virus-like particles (VLPs) as vehicle to deliver tumor-specific epitopes in the context of full-length proteins, as multi-epitope constructs or as individual tumor-associated T-cell epitopes. VLPs represent non-infectious and non-replicating antigen delivery systems devoid of any nucleic acid. They constitute innovative immunotherapeutic agents against cancer due to their superior, adjuvant-like antigenicity. We will present various tumor-associated antigens currently in different stages of development including survivin, as promising candidates for targeted tumor therapies. |
| Starting Page | 199 |
| File Format | |
| ISSN | 15552810 |
| e-ISSN | 15552810 |
| Journal | International Journal of Biomedical Science : IJBS |
| Issue Number | 3 |
| Volume Number | 3 |
| Language | English |
| Publisher | Master Publishing Group |
| Publisher Date | 2007-09-01 |
| Access Restriction | Open |
| Rights Holder | Master Publishing Group |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
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