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  1. Journal of electroanalytical chemistry (Lausanne, Switzerland)
  2. Year: 2013, Volume: 693
  3. Year: 2013, Volume: 693, Issue: Unspecified
  4. Microfabricated Microelectrode Sensor for Measuring Background and Slowly Changing Dopamine Concentrations
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Year: 2014, Volume: 731
Year: 2014, Volume: 717-718
Year: 2013, Volume: 693
Year: 2013, Volume: 693, Issue: Unspecified
Microfabricated Microelectrode Sensor for Measuring Background and Slowly Changing Dopamine Concentrations
Year: 2013, Volume: 691
Year: 2013, Volume: 688
Year: 2012, Volume: 686
Year: 2012, Volume: 682
Year: 2012, Volume: 664
Year: 2011, Volume: 663
Year: 2011, Volume: 660
Year: 2011, Volume: 659
Year: 2011, Volume: 656
Year: 2010, Volume: 645
Year: 2010, Volume: 643
Year: 2010, Volume: 642
Year: 2010, Volume: 639
Year: 2010, Volume: 638
Year: 2009, Volume: 633
Year: 2009, Volume: 630
Year: 2009, Volume: 629
Year: 2008, Volume: 618
Year: 2008, Volume: 616
Year: 2008, Volume: 614
Year: 2008, Volume: 612
Year: 2007, Volume: 600

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Microfabricated Microelectrode Sensor for Measuring Background and Slowly Changing Dopamine Concentrations

Content Provider PubMed Central
Author Dengler, Adam K. Mccarty, Gregory S.
Copyright Year 2013
Abstract The electrochemical detection of neurotransmitters in vivo has centered on fast scan cyclic voltammetry (FSCV) due to its temporal resolution, sensitivity and chemical selectivity. FSCV is a differential technique that records phasic (second-to-second) changes in the concentration of electroactive neurotransmitters such as dopamine (DA). To isolate the currents due to fluctuations in analyte concentration, in other words to make these phasic measurements, requires the subtraction of a large background current. The subtraction of this background and its volatility renders FSCV unable to determine background or slowly varying concentrations of electroactive analytes. However, there is still a need to readily determine the background and slowly changing concentrations of electroactive analytes in tissue. For example, the background concentrations of DA vary throughout the brain and can affect the dynamics of dopaminergic systems. So, this report presents a microfabricated electrochemical sensor for measuring background and slowly changing concentrations of DA in vitro with the selectivity and sensitivity of FSCV. The sensor is comprised of two microfabricated microelectrodes which are spaced 8 μm apart. Varying the applied potential of the outer electrode manipulates the local concentration of electroactive species including concentration at the inner electrode. These changes are measured at the inner electrode using FSCV. The resulting signal with calibration can determine the background and slowly changing concentration of DA with the selectivity and sensitivity of FSCV. In this study the background of DA is determined in vitro using this sensor. The DA signal is shown to be the result of adsorption/desorption at the outer electrode. Interference from ascorbate on the DA signal is shown to be minimal for this approach.
Related Links http://dx.doi.org/10.1016/j.jelechem.2013.01.022
Ending Page 33
Page Count 6
Starting Page 28
File Format PDF
ISSN 15726657
Journal Journal of electroanalytical chemistry (Lausanne, Switzerland)
Volume Number 693
Language English
Publisher Date 2013-03-01
Access Restriction Open
Subject Keyword Analytical Chemistry Electrochemistry Chemical Engineering(all) Research in Higher Education
Content Type Text
Resource Type Article
Subject Analytical Chemistry Chemical Engineering Electrochemistry
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