NDLI: Epigenetically Mediated Pathogenic Effects of Phenanthrene on Regulatory T Cells

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Epigenetically Mediated Pathogenic Effects of Phenanthrene on Regulatory T Cells

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Epigenetically Mediated Pathogenic Effects of Phenanthrene on Regulatory T Cells

Content Provider	PubMed Central
Author	Liu, Jing Zhang, Luhua Winterroth, Lisa C. Garcia, Marco Weiman, Shannon Wong, Jillian W. Sunwoo, John B. Nadeau, Kari C.
Copyright Year	2013
Abstract	Phenanthrene (Phe), a polycyclic aromatic hydrocarbon (PAH), is a major constituent of urban air pollution. There have been conflicting results regarding the role of other AhR ligands 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) and 6-formylindolo [3,2-b]carbazole (FICZ) in modifying regulatory T cell populations (Treg) or T helper (Th)17 differentiation, and the effects of Phe have been understudied. We hypothesized that different chemical entities of PAH induce Treg to become either Th2 or Th17 effector T cells through epigenetic modification of FOXP3. To determine specific effects on T cell populations by phenanthrene, primary human Treg were treated with Phe, TCDD, or FICZ and assessed for function, gene expression, and phenotype. Methylation of CpG sites within the FOXP3 locus reduced FOXP3 expression, leading to impaired Treg function and conversion of Treg into a CD4+CD25lo Th2 phenotype in Phe-treated cells. Conversely, TCDD treatment led to epigenetic modification of IL-17A and conversion of Treg to Th17 T cells. These findings present a mechanism by which exposure to AhR-ligands mediates human T cell responses and begins to elucidate the relationship between environmental exposures, immune modulation, and initiation of human disease.
Related Links	http://dx.doi.org/10.1155/2013/967029
Starting Page	967029
File Format	PDF
ISSN	16878191
e-ISSN	16878205
Journal	Journal of Toxicology
Volume Number	2013
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2013-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Toxicology Pharmacology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Toxicology Pharmacology

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