NDLI: Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

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Analysis of the upstream elements of the xenobiotic compound-inducible and positionally regulated glutathione S-transferase Ya gene.

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Functional analysis of a centromere from fission yeast: a role for centromere-specific repeated DNA sequences.

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Cleavage of a hydrophilic C-terminal domain increases growth-inhibitory activity of oncostatin M.

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Genetic exploration of interactive domains in RNA polymerase II subunits.

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Organization and expression of the chicken N-myc gene.

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Differential regulation of the N-myc gene in transfected cells and transgenic mice.

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Disruption of single-copy genes encoding acidic ribosomal proteins in Saccharomyces cerevisiae.

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Yeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin.

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Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae.

trans activation of gene expression by v-myb.

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Null alleles of SAC7 suppress temperature-sensitive actin mutations in Saccharomyces cerevisiae.

Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA.

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo.

A gene family for acidic ribosomal proteins in Schizosaccharomyces pombe: two essential and two nonessential genes.

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Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex.

SAS1 and SAS2, GTP-binding protein genes in Dictyostelium discoideum with sequence similarities to essential genes in Saccharomyces cerevisiae.

MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis.

Transcription factor requirements for in vitro formation of transcriptionally competent 5S rRNA gene chromatin.

The c-fos cyclic AMP-responsive element conveys constitutive expression to a tissue-specific promoter.

Antibody-induced mitogenicity mediated by a chimeric CD2-c-fms receptor.

Identification of mitogen-responsive ribosomal protein S6 kinase pp90rsk, a homolog of Xenopus S6 kinase II, in chicken embryo fibroblasts.

Developmentally regulated interactions of liver nuclear factors with the rat phosphoenolpyruvate carboxykinase promoter.

Organization of subtelomeric repeats in Plasmodium berghei.

RNA editing in the cytochrome b locus of the higher plant Oenothera berteriana includes a U-to-C transition.

Identification of positive and negative regulatory regions controlling expression of the cartilage matrix protein gene.

The ABF1 factor is the transcriptional activator of the L2 ribosomal protein genes in Saccharomyces cerevisiae.

A Retrotransposable Element from the Mosquito Anopheles gambiae

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Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.

Content Provider	PubMed Central
Author	Libermann, T. A. Baltimore, D.
Abstract	The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-kappa B site abolished complex formation with both purified NF-kappa B and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids containing the IL-6 promoter revealed very little activity of the promoter in U-937 monocytic cells and in HeLa cells before stimulation. However, stimulation of U-937 and HeLa cells by inducers of NF-kappa B led to a dramatic increase in CAT activity. Mutations in the NF-kappa B-binding site abolished inducibility of IL-6 promoter-cat constructs in U-937 cells by lipopolysaccharide, tumor necrosis factor alpha, the double-stranded RNA poly(IC), or phytohemagglutinin and in HeLa cells by tumor necrosis factor alpha and drastically reduced but did not completely eliminate inducibility in HeLa cells stimulated by double-stranded RNA poly(IC) or phorbol 12-myristate 13-acetate. These results suggest that NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL-6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-6 gene induction. Because NF-kappa B is involved in the control of a variety of genes activated upon inflammation, NF-kappa B may play a central role in the inflammatory response to infection and tissue injury.
Starting Page	2327
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	5
Volume Number	10
Language	English
Publisher Date	1990-05-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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