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| Content Provider | PubMed Central |
|---|---|
| Author | Guo, Ze Zhou, Bingrong Li, Wei Sun, Xuejun Luo, Dan |
| Copyright Year | 2012 |
| Abstract | Exposure of skin to solar ultraviolet (UV) radiation induces photo-damage. Ultraviolet B (UVB) is the major component of UV radiation which induces the production of reactive oxygen species (ROS) and plays an important role in photo-damage. Hydrogen gas reduces ROS and alleviates inflammation. In this study, we sought to demonstrate that hydrogen-rich saline has the effect on skin injuries caused by UVB radiation. UVB radiation was irradiated on female C57BL/6 rats to induce skin injury. Hydrogen-rich saline and nitrogen-rich saline were administered to rats by intraperitoneal injection. Skin damage was detected by microscope after injury. UVB radiation had a significant affection in tumor necrosis factor alpha, interleukin (IL)-1β and IL-6 levels, tissue superoxide dismutase, malondialdehyde and nitric oxide activity. Hydrogen-rich saline had a protective effect by altering the levels of these markers and relieved morphological skin injury. Hydrogen-rich saline protected against UVB radiation injury, possibly by reducing inflammation and oxidative stress. |
| Related Links | http://dx.doi.org/10.7555/jbr.26.20110037 |
| Ending Page | 371 |
| Page Count | 7 |
| Starting Page | 365 |
| File Format | |
| ISSN | 16748301 |
| Journal | Journal of Biomedical Research |
| Issue Number | 5 |
| Volume Number | 26 |
| Language | English |
| Publisher | Editorial Department of Journal of Biomedical Research |
| Publisher Date | 2012-09-30 |
| Access Restriction | Open |
| Rights Holder | Editorial Department of Journal of Biomedical Research |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
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