NDLI: B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses*

Content Provider	PubMed Central
Author	Crane, Deborah D. Griffin, Amanda J. Wehrly, Tara D. Bosio, Catharine M.
Abstract	B1a cells are an important source of natural antibodies, antibodies directed against T-independent antigens, and are a primary source of IL-10. Bruton's tyrosine kinase (btk) is a cytoplasmic kinase that is essential for mediating signals from the B cell receptor and is critical for development of B1a cells. Consequentially, animals lacking btk have few B1a cells, minimal antibody responses, and can preferentially generate Th1 type immune responses following infection. B1a cells have been shown to aid in protection against infection with attenuated Francisella tularensis but their role in infection mediated by fully virulent F. tularensis is not known. Therefore, we utilized mice with defective btk (XID mice) to determine the contribution of B1a cells in defense against the virulent, F. tularensis ssp. tularensis strain SchuS4. Surprisingly, XID mice displayed increased resistance to pulmonary infection with F. tularensis. Specifically, XID mice had enhanced clearance of bacteria from the lung and spleen and significantly greater survival of infection compared to wild type controls. We revealed that resistance to infection in XID mice was associated with decreased numbers of IL-10 producing B1a cells and concomitant increased numbers of IL-12 producing macrophages and IFN-γ producing NK/NKT cells. Adoptive transfer of wild type B1a cells into XID mice reversed the control of bacterial replication. Similarly, depletion of NK/NKT cells also increased bacterial burdens in XID mice. Together, our data suggest B cell-NK/NKT cell crosstalk is a critical pivot controlling survival of infection with virulent F. tularensis.
Related Links	http://dx.doi.org/10.4049/jimmunol.1202697
Ending Page	2766
Page Count	11
Starting Page	2756
File Format	PDF
ISSN	00221767
e-ISSN	15506606
Journal	Journal of immunology (Baltimore, Md. : 1950)
Issue Number	6
Volume Number	190
Language	English
Publisher Date	2013-03-15
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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