NDLI: Single-Subject Grey Matter Graphs in Alzheimer's Disease

Content Provider	PubMed Central
Author	Tijms, Betty M. Möller, Christiane Hugo, Vrenken Wink, Alle Meije Haan, Willem De Flier, Wiesje M. Van Der Stam, Cornelis J. Philip, Scheltens Barkhof, Frederik
Editor	He, Yong
Copyright Year	2013
Abstract	Coordinated patterns of cortical morphology have been described as structural graphs and previous research has demonstrated that properties of such graphs are altered in Alzheimer's disease (AD). However, it remains unknown how these alterations are related to cognitive deficits in individuals, as such graphs are restricted to group-level analysis. In the present study we investigated this question in single-subject grey matter networks. This new method extracts large-scale structural graphs where nodes represent small cortical regions that are connected by edges when they show statistical similarity. Using this method, unweighted and undirected networks were extracted from T1 weighted structural magnetic resonance imaging scans of 38 AD patients (19 female, average age 72±4 years) and 38 controls (19 females, average age 72±4 years). Group comparisons of standard graph properties were performed after correcting for grey matter volumetric measurements and were correlated to scores of general cognitive functioning. AD networks were characterised by a more random topology as indicated by a decreased small world coefficient (p = 3.53×10−5), decreased normalized clustering coefficient (p = 7.25×10−6) and decreased normalized path length (p = 1.91×10−7). Reduced normalized path length explained significantly (p = 0.004) more variance in measurements of general cognitive decline (32%) in comparison to volumetric measurements (9%). Altered path length of the parahippocampal gyrus, hippocampus, fusiform gyrus and precuneus showed the strongest relationship with cognitive decline. The present results suggest that single-subject grey matter graphs provide a concise quantification of cortical structure that has clinical value, which might be of particular importance for disease prognosis. These findings contribute to a better understanding of structural alterations and cognitive dysfunction in AD.
Related Links	http://dx.doi.org/10.1371/journal.pone.0058921
Starting Page	58921
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	3
Volume Number	8
Language	English
Publisher	Public Library of Science
Publisher Date	2013-03-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Correction: Single-Subject Grey Matter Graphs in Alzheimer's Disease

Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients

Longitudinal Grey and White Matter Changes in Frontotemporal Dementia and Alzheimer’s Disease

Circulating miRNA Biomarkers for Alzheimer's Disease

N-Acetylcholinesterase-Induced Apoptosis in Alzheimer's Disease

Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid

The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease

Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk

Adipocytokines and CD34+ Progenitor Cells in Alzheimer's Disease

Single-Subject Grey Matter Graphs in Alzheimer's Disease

Similar Documents

Correction: Single-Subject Grey Matter Graphs in Alzheimer's Disease

Grey Matter Changes in Cognitively Impaired Parkinson's Disease Patients

Longitudinal Grey and White Matter Changes in Frontotemporal Dementia and Alzheimer’s Disease

Circulating miRNA Biomarkers for Alzheimer's Disease

N-Acetylcholinesterase-Induced Apoptosis in Alzheimer's Disease

Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid

The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease

Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk

Adipocytokines and CD34+ Progenitor Cells in Alzheimer's Disease

Single-Subject Grey Matter Graphs in Alzheimer's Disease