NDLI: Alterations in Peripheral Blood B Cell Subsets and Dynamics of B Cell Responses during Human Schistosomiasis

Content Provider	PubMed Central
Author	Labuda, Lucja A. Ulysse, Ateba-ngoa Feugap, Eliane Ngoune Heeringa, Jorn J. Vlugt, Luciën E. P. M. Van Der Pires, Regina B. A. Ludovic, Mewono Kremsner, Peter G. Van, Zelm Menno C. Adegnika, Ayola A. Yazdanbakhsh, Maria Smits, Hermelijn H.
Editor	Davies, Stephen John
Copyright Year	2013
Abstract	Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level.
Related Links	http://dx.doi.org/10.1371/journal.pntd.0002094
Starting Page	2094
File Format	PDF
ISSN	19352735
e-ISSN	19352735
Journal	PLoS Neglected Tropical Diseases
Issue Number	3
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2013-03-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Pharmacology, Toxicology and Pharmaceutics(all) Public Health, Environmental and Occupational Health Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Public Health, Environmental and Occupational Health Pharmacology, Toxicology and Pharmaceutics

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