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| Content Provider | PubMed Central |
|---|---|
| Author | Oliveira, Rodini Camila Xavier, Flà via Calà Aquino Paiva, Katià cia Batista Silva Destro, Maria Fernanda De Souza Setà bal Moyses, Raquel Ajub Pedro, Michaluarte Carvalho, Marcos Brasilino Fukuyama, Erica Erina Helena, Tajara Eloiza Okamoto, Oswaldo Keith Nunes, Fabio Daumas |
| Copyright Year | 2012 |
| Abstract | The search for molecular markers to improve diagnosis, individualize treatment and predict behavior of tumors has been the focus of several studies. This study aimed to analyze homeobox gene expression profile in oral squamous cell carcinoma (OSCC) as well as to investigate whether some of these genes are relevant molecular markers of prognosis and/or tumor aggressiveness. Homeobox gene expression levels were assessed by microarrays and qRT-PCR in OSCC tissues and adjacent non-cancerous matched tissues (margin), as well as in OSCC cell lines. Analysis of microarray data revealed the expression of 147 homeobox genes, including one set of six at least 2-fold up-regulated, and another set of 34 at least 2-fold down-regulated homeobox genes in OSCC. After qRT-PCR assays, the three most up-regulated homeobox genes (HOXA5, HOXD10 and HOXD11) revealed higher and statistically significant expression levels in OSCC samples when compared to margins. Patients presenting lower expression of HOXA5 had poorer prognosis compared to those with higher expression (P=0.03). Additionally, the status of HOXA5, HOXD10 and HOXD11 expression levels in OSCC cell lines also showed a significant up-regulation when compared to normal oral keratinocytes. Results confirm the presence of three significantly upregulated (>4-fold) homeobox genes (HOXA5, HOXD10 and HOXD11) in OSCC that may play a significant role in the pathogenesis of these tumors. Moreover, since lower levels of HOXA5 predict poor prognosis, this gene may be a novel candidate for development of therapeutic strategies in OSCC. |
| Related Links | http://dx.doi.org/10.3892/ijo.2011.1321 |
| Ending Page | 1188 |
| Page Count | 9 |
| Starting Page | 1180 |
| File Format | |
| ISSN | 17912423 |
| e-ISSN | 17912423 |
| Journal | International Journal of Oncology |
| Issue Number | 4 |
| Volume Number | 40 |
| Language | English |
| Publisher | D.A. Spandidos |
| Publisher Date | 2011-12-29 |
| Access Restriction | Open |
| Rights Holder | D.A. Spandidos |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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