NDLI: Nonhomologous recombination in human cells.

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Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding.

Four distinct and unusual linker proteins in a mitotically dividing nucleus are derived from a 71-kilodalton polyprotein, lack p34cdc2 sites, and contain protein kinase A sites.

Addition of lipid substituents of mammalian protein glycosylphosphoinositol anchors.

Nucleosome-mediated disruption of transcription factor-chromatin initiation complexes at the mouse mammary tumor virus long terminal repeat in vivo.

Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits.

An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene.

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.

Exon size affects competition between splicing and cleavage-polyadenylation in the immunoglobulin mu gene.

Distinct domains of antizyme required for binding and proteolysis of ornithine decarboxylase.

Characterization of a single strong tissue-specific enhancer downstream from the three human genes encoding placental lactogen.

Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene.

DNA sequence requirements for transcriptional initiator activity in mammalian cells.

The nuclear factor YY1 participates in repression of the beta-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction.

Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells.

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

Nonhomologous recombination in human cells.

Characterization of DNA end joining in a mammalian cell nuclear extract: junction formation is accompanied by nucleotide loss, which is limited and uniform but not site specific.

Fibroblast growth factor receptors have different signaling and mitogenic potentials.

Heat shock factor can activate transcription while bound to nucleosomal DNA in Saccharomyces cerevisiae.

Attenuation of ribosomal protein S6 phosphatase activity in chicken embryo fibroblasts transformed by Rous sarcoma virus.

Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells.

Yeast intragenic transcriptional control: activation and repression sites within the coding region of the Saccharomyces cerevisiae LPD1 gene.

The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations.

Functional analysis of mouse Hoxa-7 in Saccharomyces cerevisiae: sequences outside the homeodomain base contact zone influence binding and activation.

CDC44: a putative nucleotide-binding protein required for cell cycle progression that has homology to subunits of replication factor C.

Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region.

Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520.

Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping.

The transcription factor E2F-1 mediates the autoregulation of RB gene expression.

Aberrant DNA repair and DNA replication due to an inherited enzymatic defect in human DNA ligase I.

Chromatin structure and transcriptional activity around the replication forks arrested at the 3' end of the yeast rRNA genes.

Two upstream activation sequences control the expression of the XPR2 gene in the yeast Yarrowia lipolytica.

Induction of Drosophila RNA polymerase III gene expression by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is mediated by transcription factor IIIB.

A library of yeast genomic MCM1 binding sites contains genes involved in cell cycle control, cell wall and membrane structure, and metabolism.

Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells.

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.

Mice lacking c-fos have normal hematopoietic stem cells but exhibit altered B-cell differentiation due to an impaired bone marrow environment.

Preferential repair of UV damage in highly transcribed DNA diminishes UV-induced intrachromosomal recombination in mammalian cells.

Mismatch repair of heteroduplex DNA intermediates of extrachromosomal recombination in mammalian cells.

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function.

Target cell death triggered by cytotoxic T lymphocytes: a target cell mutant distinguishes passive pore formation and active cell suicide mechanisms.

Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs.

Specific repression of the yeast silent mating locus HMR by an adjacent telomere.

In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax.

p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation.

Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.

Analysis of the VPE sequences in the Caenorhabditis elegans vit-2 promoter with extrachromosomal tandem array-containing transgenic strains.

Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.

Interactions between DNA-bound trimers of the yeast heat shock factor.

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

The C-protein tetramer binds 230 to 240 nucleotides of pre-mRNA and nucleates the assembly of 40S heterogeneous nuclear ribonucleoprotein particles.

Functional evidence for a second tumor suppressor gene on human chromosome 17.

Modulation of transcriptional activation of the proliferating cell nuclear antigen promoter by the adenovirus E1A 243-residue oncoprotein depends on proximal activators.

Telomeric DNA sequence and structure following de novo telomere synthesis in Euplotes crassus.

Alternative 5' splice site selection induced by heat shock.

The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit.

Selection for arsenite resistance causes reversible changes in minicircle composition and kinetoplast organization in Leishmania mexicana.

TATA box-binding protein (TBP) is a constituent of the polymerase I-specific transcription initiation factor TIF-IB (SL1) bound to the rRNA promoter and shows differential sensitivity to TBP-directed reagents in polymerase I, II, and III transcription factors.

Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control.

Enhanced translational efficiency of a novel transforming growth factor beta 3 mRNA in human breast cancer cells.

Dissection of the ADR1 protein reveals multiple, functionally redundant activation domains interspersed with inhibitory regions: evidence for a repressor binding to the ADR1c region.

Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.

NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype.

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway.

Intragenic activating and repressing elements control transcription from the adenovirus IVa2 initiator.

Binding of TFIID and MEF2 to the TATA element activates transcription of the Xenopus MyoDa promoter.

Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun.

The Drosophila dorsal morphogen represses the tolloid gene by interacting with a silencer element.

TATA-binding protein and nuclear differentiation in Tetrahymena thermophila.

Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.

The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization.

Expression and function of TRK-B and BDNF in human neuroblastomas.

Interaction between the Cig1 and Cig2 B-type cyclins in the fission yeast cell cycle.

Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells.

MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells.

Functional analysis of the V gamma 3 promoter of the murine gamma delta T-cell receptor.

Functional significance of lysine 1423 of neurofibromin and characterization of a second site suppressor which rescues mutations at this residue and suppresses RAS2Val-19-activated phenotypes.

A mutation in the second largest subunit of TFIIIC increases a rate-limiting step in transcription by RNA polymerase III.

MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3.

Cooperative binding of Ets-1 and core binding factor to DNA.

Loss of thrombospondin transcriptional activity in nickel-transformed cells.

Evidence for a role of the Drosophila melanogaster suppressor of sable gene in the pre-mRNA splicing pathway.

Transcriptional up-regulation of the mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3' enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors.

Two Fission Yeast B-Type Cyclins, Cig2 and Cdc13, Have Different Functions in Mitosis

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Nonhomologous recombination in human cells.

Content Provider	PubMed Central
Author	Derbyshire, M. K. Epstein, L. H. Young, C. S. Munz, P. L. Fishel, R.
Abstract	Nonhomologous recombination (NHR) is a major pathway for the repair of chromosomal double-strand breaks in the DNA of somatic cells. In this study, a comparison was made between the nonhomologous end joining of transfected adenovirus DNA fragments in vivo and the ability of purified human proteins to catalyze nonhomologous end joining in vitro. Adenovirus DNA fragments were shown to be efficiently joined in human cells regardless of the structure of the ends. Sequence analysis of these junctions revealed that the two participating ends frequently lost nucleotides from the 3' strands at the site of the joint. To examine the biochemical basis of the end joining, nuclear extracts were prepared from a wide variety of mammalian cell lines and tested for their ability to join test plasmid substrates. Efficient ligation of the linear substrate DNA was observed, the in vitro products being similar to the in vivo products with respect to the loss of 3' nucleotides at the junction. Substantial purification of the end-joining activity was carried out with the human immature T-cell-line HPB-ALL. The protein preparation was found to join all types of linear DNA substrates containing heterologous ends with closely equivalent efficiencies. The in vitro system for end joining does not appear to contain any of the three known DNA ligases, on the basis of a number of criteria, and has been termed the NHR ligase. The enriched activity resides in a high-molecular-weight recombination complex that appears to include and require the human homologous pairing protein HPP-1 as well as the NHR ligase. Characterization of the product molecules of the NHR ligase reaction suggests that they are linear oligomers of the monomer substrate joined nonrandomly head-to-head and/or tail-to-tail. The joined ends of the products were found to be modified by a 3' exonuclease prior to ligation, and no circular DNA molecules were detected. These types of products are similar to those required for the breakage-fusion-bridge cycle, a major NHR pathway for chromosome double-strand break repair.
Starting Page	156
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	1
Volume Number	14
Language	English
Publisher Date	1994-01-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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