NDLI: Designer Gap Junctions that Prevent Cardiac Arrhythmias

Content Provider	PubMed Central
Author	Kim, Eugene Fishman, Glenn I.
Copyright Year	2012
Abstract	Cardiac gap junctions are specialized membrane structures comprised of arrays of intercellular channels responsible for propagation of the cardiac impulse. These channels are formed by oligomerization of individual protein subunits known as connexins. In response to a broad array of pathologic stressors, gap junction expression is disturbed, resulting in aberrant cardiac conduction and increased propensity for rhythm disturbances. In this article we review some of the recently identified molecular regulators of connexin assembly, membrane targeting and degradation, focusing on the role of post-translational phosphorylation of connexin43, the major gap junctional protein expressed in ventricular myocardium. We also describe efforts to engineer “designer” gap junctions that are resistant to pathologic remodeling.
Related Links	http://dx.doi.org/10.1016/j.tcm.2012.08.008
Ending Page	38
Page Count	6
Starting Page	33
File Format	PDF
ISSN	18732615
e-ISSN	18732615
Journal	Trends in cardiovascular medicine
Issue Number	2
Volume Number	23
Language	English
Publisher Date	2013-02-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Designer Gap Junctions that Prevent Cardiac Arrhythmias