NDLI: Electroretinogram analysis of relative spectral sensitivity in genetically identified dichromatic macaques

Content Provider	PubMed Central
Author	Hanazawa, Akitoshi Mikami, Akichika Angelika, Puti Sulistyo Takenaka, Osamu Goto, Shunji Onishi, Akishi Koike, Satoshi Yamamori, Tetsuo Kato, Keichiro Kondo, Aya Suryobroto, Bambang Achmad, Farajallah Komatsu, Hidehiko
Copyright Year	2001
Abstract	The retinas of macaque monkeys usually contain three types of photopigment, providing them with trichromatic color vision homologous to that of humans. However, we recently used molecular genetic analysis to identify several macaques with a dichromatic genotype. The affected X chromosome of these animals contains a hybrid gene of long-wavelength-sensitive (L) and middle-wavelength-sensitive (M) photopigments instead of separate genes encoding L and M photopigments. The product of the hybrid gene exhibits a spectral sensitivity close to that of M photopigment; consequently, male monkeys carrying the hybrid gene are genetic protanopes, effectively lacking L photopigment. In the present study, we assessed retinal expression of L photopigment in monkeys carrying the hybrid gene. The relative sensitivities to middle-wavelength (green) and long-wavelength (red) light were measured by electroretinogram flicker photometry. We found the sensitivity to red light to be extremely low in protanopic male monkeys compared with monkeys with the normal genotype. In female heterozygotes, sensitivity to red light was intermediate between the genetic protanopes and normal monkeys. Decreased sensitivity to long wavelengths was thus consistent with genetic loss of L photopigment.
Related Links	http://dx.doi.org/10.1073/pnas.141236598
Starting Page	8124
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	98
Language	English
Publisher	The National Academy of Sciences
Publisher Date	2001-07-03
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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